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功能磁共振复杂度与晚发性和常染色体显性阿尔茨海默病的 Tau-PET 和认知下降相关。

FMRI Complexity Correlates with Tau-PET and Cognitive Decline in Late-Onset and Autosomal Dominant Alzheimer's Disease.

机构信息

Laboratory of Functional MRI Technology (LOFT), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

出版信息

J Alzheimers Dis. 2023;95(2):437-451. doi: 10.3233/JAD-220851.

DOI:10.3233/JAD-220851
PMID:37599531
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10578217/
Abstract

BACKGROUND

Neurofibrillary tangle pathology detected with tau-PET correlates closely with neuronal injury and cognitive symptoms in Alzheimer's disease (AD). Complexity of rs-fMRI has been demonstrated to decrease with cognitive decline in AD.

OBJECTIVE

We hypothesize that the rs-fMRI complexity provides an index for tau-related neuronal injury and cognitive decline in the AD process.

METHODS

Data was obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI3) and the Estudio de la Enfermedad de Alzheimer en Jalisciences (EEAJ) study. Associations between tau-PET and rs-fMRI complexity were calculated. Potential pathways relating complexity to cognitive function mediated through tau-PET were assessed by path analysis.

RESULTS

We found significant negative correlations between rs-fMRI complexity and tau-PET in medial temporal lobe of both cohorts, and associations of rs-fMRI complexity with cognitive scores were mediated through tau-PET.

CONCLUSION

The association of rs-fMRI complexity with tau-PET and cognition, suggests that a reduction in complexity is indicative of tau-related neuropathology and cognitive decline in AD processes.

摘要

背景

tau-PET 检测到的神经原纤维缠结病理与阿尔茨海默病（AD）中的神经元损伤和认知症状密切相关。rs-fMRI 的复杂性已被证明随着 AD 认知能力下降而降低。

目的

我们假设 rs-fMRI 的复杂性为 AD 过程中与 tau 相关的神经元损伤和认知下降提供了一个指标。

方法

数据来自阿尔茨海默病神经影像学倡议（ADNI3）和 Jalisciences 阿尔茨海默病研究（EEAJ）。计算 tau-PET 与 rs-fMRI 复杂性之间的关联。通过路径分析评估通过 tau-PET 介导的与认知功能相关的复杂性的潜在途径。

结果

我们发现两个队列的内侧颞叶 rs-fMRI 复杂性与 tau-PET 之间存在显著负相关，rs-fMRI 复杂性与认知评分的关联通过 tau-PET 介导。

结论

rs-fMRI 复杂性与 tau-PET 和认知的关联表明，复杂性的降低表明 AD 过程中与 tau 相关的神经病理学和认知下降。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1622/10578217/b0776fe22a77/jad-95-jad220851-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1622/10578217/006c47eb44e0/jad-95-jad220851-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1622/10578217/8245d997aeb7/jad-95-jad220851-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1622/10578217/d9acfc769427/jad-95-jad220851-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1622/10578217/31ff15de3fe5/jad-95-jad220851-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1622/10578217/bd97c770739e/jad-95-jad220851-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1622/10578217/3dd1e23671fd/jad-95-jad220851-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1622/10578217/b0776fe22a77/jad-95-jad220851-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1622/10578217/006c47eb44e0/jad-95-jad220851-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1622/10578217/8245d997aeb7/jad-95-jad220851-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1622/10578217/d9acfc769427/jad-95-jad220851-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1622/10578217/31ff15de3fe5/jad-95-jad220851-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1622/10578217/bd97c770739e/jad-95-jad220851-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1622/10578217/3dd1e23671fd/jad-95-jad220851-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1622/10578217/b0776fe22a77/jad-95-jad220851-g007.jpg

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