Department of Dermatology, Venereology and Leprosy, Father Muller Medical College, Mangalore, India.
Arch Dermatol Res. 2024 Aug 23;316(8):564. doi: 10.1007/s00403-024-03327-z.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous reactions, usually to drugs, characterized by blistering and epithelial sloughing. SCORTEN is an established prognosticator index employed in SJS/TEN patients to evaluate their severity degree and mortality risk. Many studies done in the recent past have indicated that neutrophil-lymphocyte ratio (NLR) is related to disease activity in several dermatological diseases. Hence, this study has been performed to correlate the NLR of each patient with their respective SCORTEN values and assess whether NLR can be used as a prognostic marker in SJS/TEN. A single centre, retrospective, 4 year study was conducted at a tertiary care hospital. The required clinical and laboratory data were obtained from existing IP records of all cases of SJS/TEN disorders admitted in the last 4 years in our hospital between May 1st 2019 and April 30th 2023. The correlation coefficient and p value were analysed using the Spearman's rank correlation. The total sample size of the study was 22 patients. A female preponderance (59.1%) with an age range between 10 to 74 years was noted. Drugs were the main triggering factor in all the patients and antiepileptics were the most commonly implicated drug group. On statistical analysis a weak positive correlation (r = 0.182) between NLR and SCORTEN was noted, however p value was insignificant (p = 0.417). Further, mean ± SD of NLR was found to be higher in group II (patients with SCORTEN ≥ 3) as compared to group I (patients with SCORTEN < 3). On correlating NLR with each group separately, p value still remained insignificant. Elevation in NLR value reflects the systemic inflammation, but its role in predicting the severity of the disease needs further research involving larger sample size.
史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）是严重的黏膜皮肤反应，通常由药物引起，表现为水疱和上皮脱落。SCORTEN 是一种已建立的预后指数，用于评估 SJS/TEN 患者的严重程度和死亡风险。最近的许多研究表明，中性粒细胞-淋巴细胞比值（NLR）与几种皮肤病的疾病活动有关。因此，本研究旨在将每位患者的 NLR 与其各自的 SCORTEN 值相关联，并评估 NLR 是否可作为 SJS/TEN 的预后标志物。一项在三级保健医院进行的单中心、回顾性、4 年研究。从 2019 年 5 月 1 日至 2023 年 4 月 30 日期间我院收治的 SJS/TEN 障碍患者的现有 IP 记录中获得所需的临床和实验室数据。使用 Spearman 等级相关分析来分析相关系数和 p 值。本研究的总样本量为 22 例患者。女性占优势（59.1%），年龄在 10 至 74 岁之间。所有患者的主要触发因素均为药物，抗癫痫药是最常见的相关药物组。在统计分析中，NLR 与 SCORTEN 之间存在微弱的正相关（r=0.182），但 p 值无统计学意义（p=0.417）。此外，发现 NLR 的平均值（±SD）在 SCORTEN≥3 的第 II 组（患者）中高于第 I 组（患者）（SCORTEN<3）。分别将 NLR 与每组相关联时，p 值仍无统计学意义。NLR 值的升高反映了全身炎症，但它在预测疾病严重程度方面的作用需要进一步研究，涉及更大的样本量。
