Corrin B, Basset F
Invest Cell Pathol. 1979 Jul-Sep;2(3):137-46.
Electron microscopy confirms the unity of Histiocytosis X (HX) by identifying a common marker organelle in all three forms of the disease (acute disseminated HX or Letterer-Siwe disease; chronic disseminated HX or Hand-Schuller-Christian disease; localized HX or eosinophilic granuloma). The marker organelle of HX is also found in normal Langerhans' cells: these mononuclear cells are distinct from macrophages but are similarly concerned in antigen transport. HX may therefore be considered to represent a pathological proliferation of Langerhans' cells. The natural history and the clinical, radiological and pathological features of primary pulmonary HX (eosinophilic granuloma of the lungs) are described, together with the differential diagnoses which must be considered by the histopathologist.
电子显微镜检查通过在组织细胞增多症X（HX）的所有三种形式（急性播散性HX或勒-雪病；慢性播散性HX或汉-许-克病；局限性HX或嗜酸性肉芽肿）中识别出一种共同的标志性细胞器，证实了HX的统一性。HX的标志性细胞器也存在于正常朗格汉斯细胞中：这些单核细胞与巨噬细胞不同，但同样参与抗原转运。因此，HX可被认为代表朗格汉斯细胞的病理性增殖。本文描述了原发性肺HX（肺嗜酸性肉芽肿）的自然病程以及临床、放射学和病理学特征，同时也介绍了组织病理学家必须考虑的鉴别诊断。
