Jiang Wen, Zheng Bohao, Wei Hongquan
China Medical University, Shengyang, China.
Department of Otorhinolaryngology, First Affiliated Hospital of China Medical University, Shenyang, China.
Discov Oncol. 2024 Aug 23;15(1):365. doi: 10.1007/s12672-024-01242-3.
Nasopharyngeal carcinoma (NPC) arises from the mucosal epithelium of the nasopharynx and is frequently located in the pharyngeal crypts. This is a highly aggressive malignant tumor that frequently leads to distant metastases in many cases and poses a significant public health challenge, particularly in certain geographic regions globally. This review discusses the epidemiology, risk factors, diagnosis, and treatment options for NPC, emphasizing the importance of early detection and comprehensive management strategies in improving patient outcomes. Moreover, the article explores the intricate mechanisms that cause NPC. Comprehending these fundamental principles can assist in creating specific prevention and therapy approaches for NPC. Recent advances in diagnostic methods, including imaging tests and molecular biomarkers, are emphasized to improve early diagnosis and individualized treatment strategies for individuals with NPC. The review also explores the most recent advancements in treating early-stage (stage I and II) NPC patients, highlighting the changing landscape of individualized therapy approaches for this particular set of patients.
鼻咽癌（NPC）起源于鼻咽部的黏膜上皮，常位于咽隐窝。这是一种侵袭性很强的恶性肿瘤，在许多情况下常导致远处转移，对公共卫生构成重大挑战，特别是在全球某些地理区域。本综述讨论了鼻咽癌的流行病学、危险因素、诊断和治疗选择，强调了早期检测和综合管理策略对改善患者预后的重要性。此外，本文还探讨了导致鼻咽癌的复杂机制。理解这些基本原理有助于制定针对鼻咽癌的特定预防和治疗方法。文中强调了诊断方法的最新进展，包括影像学检查和分子生物标志物，以改善鼻咽癌患者的早期诊断和个体化治疗策略。该综述还探讨了早期（I期和II期）鼻咽癌患者治疗的最新进展，突出了针对这组特定患者的个体化治疗方法的不断变化的格局。
