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使用幂律溶血模型中不同系数集和标量剪切应力模型对美国食品药品监督管理局基准血泵进行计算流体动力学模拟。

Computational fluid dynamics simulating of the FDA benchmark blood pump with different coefficient sets and scaler shear stress models used in the power-law hemolysis model.

作者信息

Onder Ahmet, Incebay Omer, Yapici Rafet

机构信息

Technical Sciences Vocational School, Mechanical and Metal Technologies Department, Konya Technical University, Konya, Turkey.

Faculty of Engineering and Natural Science, Mechanical Engineering Department, Konya Technical University, Konya, Turkey.

出版信息

J Artif Organs. 2025 Jun;28(2):184-191. doi: 10.1007/s10047-024-01468-6. Epub 2024 Aug 23.

Abstract

Hemolysis is the most important issue to consider in the design and optimization of blood-contacting devices. Although the use of Computational Fluid Dynamics (CFD) in hemolysis prediction studies provides convenience and has promising potential, it is an extremely challenging process. Hemolysis predictions with CFD depend on the mesh, implementation method, coefficient set, and scalar-shear-stress model. To this end, an attempt was made to find the combination that would provide the most accurate result in hemolysis prediction with the commonly cited power-law based hemolysis model. In the hemolysis predictions conducted using CFD on the Food and Drug Administration (FDA) benchmark blood pump, 3 different scalar-shear-stress models, and 5 different coefficient sets with the power-law based hemolysis model were used. Also, a mesh independence test based on hemolysis and pressure head was performed. The pressure head results of CFD simulations were compared with published pressure head of the FDA benchmark blood pump and a good agreement was observed. In addition, results of CFD-hemolysis predictions which are conducted with scalar-shear-stress model and coefficient set combinations were compared with experimental hemolysis data at three operating conditions such as 6-7 L/min flow rates at 3500 rpm rotational speeds and 6 L/min at 2500 rpm. One of the combinations of the scalar-shear-stress model and the coefficient set was found to be within the error limits of the experimental measurements, while all other combinations overestimated hemolysis.

摘要

溶血是血液接触装置设计和优化中需要考虑的最重要问题。虽然在溶血预测研究中使用计算流体动力学(CFD)提供了便利且具有广阔的潜力,但这是一个极具挑战性的过程。基于CFD的溶血预测取决于网格、实现方法、系数集和标量剪切应力模型。为此,人们试图找到一种组合,在基于常用幂律的溶血模型进行溶血预测时能提供最准确的结果。在使用CFD对美国食品药品监督管理局(FDA)基准血泵进行的溶血预测中,使用了3种不同的标量剪切应力模型以及基于幂律溶血模型的5种不同系数集。此外,还基于溶血和压头进行了网格独立性测试。将CFD模拟的压头结果与FDA基准血泵已发表的压头进行比较,观察到良好的一致性。另外,将使用标量剪切应力模型和系数集组合进行的CFD溶血预测结果与在三种运行条件下的实验溶血数据进行比较,这三种运行条件分别为:转速3500转/分钟时流速6 - 7升/分钟以及转速2500转/分钟时流速6升/分钟。结果发现,标量剪切应力模型和系数集的一种组合在实验测量的误差范围内,而所有其他组合均高估了溶血情况。

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