Langman M J, Morgan L, Worrall A
Br Med J (Clin Res Ed). 1985 Feb 2;290(6465):347-9. doi: 10.1136/bmj.290.6465.347.
The intake of anti-inflammatory drugs by 268 patients with colonic or small bowel perforation or haemorrhage was compared with that by a group of patients, matched for age and sex, with uncomplicated lower bowel disease. Patients with perforation or haemorrhage were more than twice as likely to be takers of anti-inflammatory drugs, but no association was detected with the intake of other types of drugs, particularly cardiovascular drugs. The association between complicated lower bowel disease and intake of anti-inflammatory drugs may be causal.
将268例结肠或小肠穿孔或出血患者的抗炎药摄入量与一组年龄和性别匹配的患有非复杂性下消化道疾病的患者进行了比较。穿孔或出血患者服用抗炎药的可能性是后者的两倍多,但未发现与其他类型药物(尤其是心血管药物)的摄入存在关联。复杂性下消化道疾病与抗炎药摄入之间的关联可能是因果关系。