Department of Surgery, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.
Department of Obstetrics, Gynaecology, and Reproduction. Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.
Vet J. 2024 Dec;308:106227. doi: 10.1016/j.tvjl.2024.106227. Epub 2024 Aug 22.
Osteoarthritis (OA) is the most common orthopedic disorder characterized by chronic inflammation and pain in dogs and cats. Cannabis spp. contains cannabidiol (CBD), a substance with pain relief and anti-inflammatory properties in different animals including dogs with OA. The use of CBD supplements has been increasingly intertwining in veterinary medicine. This study aimed to evaluate the clinical efficacy of CBD + krill oil-supplemented biscuit against canine OA. In total, 30 dogs with stifle OA were randomized and divided into the placebo, krill oil, and CBD + krill oil groups. The Canine Brief Pain Inventory questionnaire was used to evaluate the efficacy of each treatment against pain. Stifle temperature was monitored to identify degrees of stifle inflammation. Two and one dogs in the placebo group were excluded from the study due to worsening lameness and increased pain interference score (PIS) and pain severity score (PSS) at days 14 and 28, respectively. The PIS and PSS scores of the krill oil and CBD + krill oil groups gradually and significantly improved after two weeks of treatment. The CBD + krill oil group had better PIS and PSS scores than the placebo and krill oil groups. However, there was no statistically significant difference in the PIS and PSS scores between the krill oil and CBD + krill oil groups. The stifle temperature of the three groups at different periods did not significantly differ. In conclusion, CBD + krill oil supplements are safe against canine OA. CBD can reduce pain and inflammation.
骨关节炎（OA）是最常见的骨科疾病，其特征为犬猫的慢性炎症和疼痛。大麻素含有大麻二酚（CBD），这种物质具有缓解疼痛和抗炎特性，在包括患有 OA 的犬类在内的不同动物中均有体现。CBD 补充剂的使用在兽医领域越来越普遍。本研究旨在评估 CBD +磷虾油补充饼干对犬 OA 的临床疗效。共有 30 只患有 stifle OA 的犬被随机分为安慰剂组、磷虾油组和 CBD +磷虾油组。采用犬简明疼痛量表问卷评估每种治疗方法对疼痛的疗效。监测 stifle 温度以确定 stifle 炎症程度。由于在第 14 天和第 28 天跛行加重和疼痛干扰评分（PIS）和疼痛严重程度评分（PSS）增加，安慰剂组中有 2 只和 1 只犬被排除在研究之外。磷虾油和 CBD +磷虾油组在治疗两周后 PIS 和 PSS 评分逐渐显著改善。与安慰剂和磷虾油组相比，CBD +磷虾油组的 PIS 和 PSS 评分更好。然而，磷虾油和 CBD +磷虾油组之间的 PIS 和 PSS 评分无统计学差异。三组在不同时期的 stifle 温度没有显著差异。总之，CBD +磷虾油补充剂对犬 OA 是安全的。CBD 可以减轻疼痛和炎症。
