Graduate School of Health and Sports Science, Juntendo University, Inzai, Chiba, Japan.
Faculty of Health and Sports Science, Juntendo University, Inzai, Chiba, Japan.
PLoS One. 2016 Oct 4;11(10):e0162769. doi: 10.1371/journal.pone.0162769. eCollection 2016.
Krill oil is an edible oil extracted from krill, a small red-colored crustacean found in the Antarctic Ocean. The administration of krill oil is reported to mitigate inflammation in patients with cardiac disease, rheumatoid arthritis, or osteoarthritis. However, the effect of krill oil on mild knee pain has not yet been determined.
To assess the effect of krill oil on mild knee pain.
A randomized, double-blind, parallel-group, placebo-controlled trial of fifty adults (38-85 years old) with mild knee pain attending the Fukushima Orthopedic Clinic (Tochigi, Japan) between September 2014 and March 2015.
Participants were randomized to receive 2 g per day of either krill oil or an identical placebo for 30 days.
The primary outcome was improvement in subjective symptoms of knee pain as assessed by the Japanese Knee Osteoarthritis Measure (JKOM) and Japanese Orthopaedic Association score (JOA). Secondary outcomes included blood and urine biochemical parameters.
Both the placebo and krill oil groups showed significant improvements in the questions in the JKOM and JOA questionnaires after administration. After the intervention, krill oil group showed more improvements than placebo group in two questions regarding the pain and stiffness in knees in JKOM. Controlling for age, sex, weight, and smoking and drinking habits, krill oil significantly mitigated knee pain in sleeping (P < 0.001), standing (P < 0.001) and the range of motion of both right and left knees (both P = 0.011) compared to placebo. Krill oil administration raised plasma EPA (P = 0.048) and EPA/AA ratio (P = 0.003).
This study indicates that krill oil administration (2 g/day, 30 days) improved the subjective symptoms of knee pain in adults with mild knee pain.
UMIN-CTR; ID UMIN000014413.
磷虾油是从南极磷虾中提取的可食用油。据报道，磷虾油的摄入可以减轻心脏病、类风湿关节炎或骨关节炎患者的炎症。然而，磷虾油对轻度膝痛的影响尚未确定。
评估磷虾油对轻度膝痛的影响。
这是一项在日本福岛骨科诊所（Tochigi）招募的 50 名成年人（38-85 岁）参加的随机、双盲、平行组、安慰剂对照试验，这些成年人患有轻度膝痛。研究时间为 2014 年 9 月至 2015 年 3 月。
参与者被随机分为每天接受 2 克磷虾油或相同安慰剂的两组，持续 30 天。
主要结局是用日本膝关节骨关节炎量表（JKOM）和日本矫形协会评分（JOA）评估的膝关节疼痛主观症状的改善。次要结局包括血液和尿液生化参数。
在服用后，安慰剂组和磷虾油组在 JKOM 和 JOA 问卷的问题上都显示出显著改善。干预后，在 JKOM 中关于膝关节疼痛和僵硬的两个问题上，磷虾油组比安慰剂组有更多的改善。控制年龄、性别、体重以及吸烟和饮酒习惯后，与安慰剂相比，磷虾油在睡眠时（P < 0.001）、站立时（P < 0.001）以及左右膝关节活动度（均 P = 0.011）时膝关节疼痛的缓解更为显著。磷虾油的摄入使血浆 EPA（P = 0.048）和 EPA/AA 比值（P = 0.003）升高。
本研究表明，磷虾油的摄入（每天 2 克，持续 30 天）可改善轻度膝痛成年人的膝关节疼痛主观症状。
UMIN-CTR；ID UMIN000014413。
