Reindollar R H, Moretuzzo R W, Ellegood J O, Mahesh V B, McDonough P G
Fertil Steril. 1985 Feb;43(2):185-95. doi: 10.1016/s0015-0282(16)48371-8.
Ten ovulatory women were followed with gonadotropin and steroid determinations through two cycles. They were given 500 micrograms of luteinizing hormone-releasing hormone (LH-RH) during the periovulatory period of the second cycle to determine whether ovulation could be facilitated without altering corpus luteum function. Successive cycles demonstrated concordance for patterns of gonadotropin and steroid secretion when studied as group means. Two control cycles and one treatment cycle were consistent with luteal phase defects. The use of a supramaximal dose of LH-RH in these women neither facilitated ovulation nor adversely affected luteal function. A significant linear correlation was noted between peak LH and follicle-stimulating hormone (FSH) values for the spontaneous surges. This same linear relationship was maintained for the LH and FSH responses to 500 micrograms LH-RH. The present data produce further evidence demonstrating that the secretion of LH and FSH appears to be modulated by gonadal steroids and under the permissive control of a single gonadotropin-releasing hormone.
对10名有排卵的女性进行了两个周期的促性腺激素和类固醇测定跟踪。在第二个周期的排卵期，给她们注射500微克促黄体生成激素释放激素（LH-RH），以确定在不改变黄体功能的情况下是否能促进排卵。当作为组均值进行研究时，连续的周期显示促性腺激素和类固醇分泌模式具有一致性。两个对照周期和一个治疗周期均符合黄体期缺陷。在这些女性中使用超最大剂量的LH-RH既没有促进排卵，也没有对黄体功能产生不利影响。在自发高峰时，LH峰值与促卵泡生成素（FSH）值之间存在显著的线性相关性。对于对500微克LH-RH的LH和FSH反应，同样的线性关系得以维持。目前的数据进一步证明，LH和FSH的分泌似乎受性腺类固醇调节，并受单一促性腺激素释放激素的允许性控制。
