Grimes E M, Taymor M L, Thompson I E
Fertil Steril. 1975 Mar;26(3):277-82. doi: 10.1016/s0015-0282(16)40997-0.
Synthetic LH-RH was administered by various routes to 19 patients during 37 treatment cycles in an attempt to trigger ovulation in association with insemination therapy. Thirty-five cycles were ovulatory; four pregnancies occurred, but two of them ended in spontaneous abortion. In 20 cycles, the hyperthermia response occurred one to three days after LH-RH administration, suggesting that ovulation occurred as a direct consequence of administered LH-RH. Low levels and delayed peak secretion of progesterone were found in two patients who had serial progesterone determinations during the luteal phase after LH-RH administration. Ovulation timing with LH-RH appears feasible, but efforts to ensure the availability of a mature follicle are required.
在37个治疗周期中，对19名患者采用多种途径给予合成促黄体生成素释放激素（LH-RH），试图在人工授精治疗的同时触发排卵。35个周期出现排卵；发生了4次妊娠，但其中2次以自然流产告终。在20个周期中，在给予LH-RH后1至3天出现体温升高反应，提示排卵是所给予的LH-RH直接导致的结果。在给予LH-RH后黄体期进行连续孕酮测定的2名患者中，发现孕酮水平低且峰值分泌延迟。使用LH-RH确定排卵时间似乎可行，但需要努力确保有成熟卵泡。
