595nm 脉冲染料激光联合超分子水杨酸治疗酒渣鼻的临床疗效。
Clinical efficacy of 595 nm pulsed dye laser in combination with supramolecular salicylic acid in the treatment of rosacea.
机构信息
Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan, 430000, Hubei, China.
Department of Dermatology, No.1 Hospital of China Medical University, 155 North Nanjing Street, Shenyang, 110001, Liaoning, China.
出版信息
Arch Dermatol Res. 2024 Aug 24;316(8):579. doi: 10.1007/s00403-024-03290-9.
OBJECTIVE
This research was aimed at ascertaining the clinical effects of 595 nm pulsed dye laser (PDL) in combination with supramolecular salicylic acid (SSA) in the treatment of rosacea.
METHODS
Eighty-four patients with rosacea were selected, of which 42 patients treated with PDL alone were considered as the control group, and 42 patients treated with 595 nm PDL in combination with 30% SSA were regarded as the observation group. The treatment continued for 4 months in the two groups. Clinical symptom scores, skin barrier function indicators, serum inflammatory factors, Acne⁃QOL scores and adverse reactions between the two groups were compared.
RESULTS
After treatment, levels of inflammatory factors, clinical symptom scores, transdermal water loss, and oil volume were decreased, and epidermal water content and Acne-QOL scores were increased in both groups (all P < 0.05), and the changes in the observation group were more pronounced versus the control group (all P < 0.05). The difference in the incidence of adverse reactions was not statistically significant between the two groups (P > 0.05).
CONCLUSION
595 nm PDL in combination with SSA is safe in the treatment of rosacea.
目的
本研究旨在确定 595nm 脉冲染料激光（PDL）联合超分子水杨酸（SSA）治疗酒渣鼻的临床疗效。
方法
选取 84 例酒渣鼻患者，其中 42 例单纯接受 PDL 治疗的患者作为对照组，42 例接受 595nm PDL 联合 30%SSA 治疗的患者作为观察组。两组均持续治疗 4 个月。比较两组患者的临床症状评分、皮肤屏障功能指标、血清炎症因子、痤疮生活质量量表（Acne-QOL）评分及不良反应。
结果
治疗后，两组患者的炎症因子水平、临床症状评分、经皮水分丢失量和皮脂量均降低，表皮水分含量和 Acne-QOL 评分均升高（均 P<0.05），且观察组的变化均优于对照组（均 P<0.05）。两组不良反应发生率的差异无统计学意义（P>0.05）。
结论
595nm PDL 联合 SSA 治疗酒渣鼻安全有效。
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