Xu Linghui, Yao Boxin, Xu Tianxing, Huang Huang
Department of Dermatology, The Second Affiliated Hospital of Fujian Medical University, No. 950, Donghai Avenue, Quanzhou City, Fujian Province, China.
Department of Neurology, The Second Affiliated Hospital of Fujian Medical University, No. 950, Donghai Avenue, Quanzhou City, Fujian Province, China.
Indian J Dermatol. 2022 Sep-Oct;67(5):625. doi: 10.4103/ijd.ijd_353_21.
Thirty per cent supramolecular salicylic acid (SSA) is a water-soluble, sustained release salicylic acid (SA) modality, which is well tolerated by sensitive skin. Anti-inflammatory therapy plays an important role in papulopustular rosacea (PPR) treatment. SSA at a 30% concentration has a natural antiinflammatory property.
This study aims to investigate the efficacy and safety of 30% SSA peeling for PPR treatment.
Sixty PPR patients were randomly divided into two groups: SSA group (30 cases) and control group (30 cases). Patients of the SSA group were treated with 30% SSA peeling three times every 3 weeks. Patients in both groups were instructed to topically apply 0.75% metronidazole gel twice daily. Transdermal water loss (TEWL), skin hydration and erythema index were assessed after 9 weeks.
Fifty-eight patients completed the study. The improvement of erythema index in the SSA group was significantly better than that in the control group. No significant difference was found in terms of TEWL between the two groups. The content of skin hydration in both the groups increased, but there was no statistical significance. No severe adverse events were observed in both the groups.
SSA can significantly improve the erythema index and overall appearance of skin in rosacea patients. It has a good therapeutic effect, good tolerance and high safety.
30%超分子水杨酸（SSA）是一种水溶性、缓释型水杨酸（SA）剂型，敏感皮肤对其耐受性良好。抗炎治疗在丘疹脓疱型玫瑰痤疮（PPR）的治疗中起着重要作用。浓度为30%的SSA具有天然的抗炎特性。
本研究旨在探讨30%SSA剥脱术治疗PPR的疗效和安全性。
60例PPR患者随机分为两组：SSA组（30例）和对照组（30例）。SSA组患者每3周接受3次30%SSA剥脱术治疗。两组患者均被指导每天外用0.75%甲硝唑凝胶两次。9周后评估经皮水分流失（TEWL）、皮肤水合作用和红斑指数。
58例患者完成了研究。SSA组红斑指数的改善明显优于对照组。两组之间在TEWL方面未发现显著差异。两组皮肤水合作用的含量均增加，但无统计学意义。两组均未观察到严重不良事件。
SSA可显著改善玫瑰痤疮患者的红斑指数和皮肤整体外观。其具有良好的治疗效果、耐受性和高安全性。
