Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Beijing Diabetes Institute, Beijing 100730, China; Beijing Key Laboratory of Diabetes Research and Care, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China.
Beijing Municipal Health Big Data and Policy Research Center, Beijing 100034, China.
Med. 2024 Nov 8;5(11):1402-1412.e2. doi: 10.1016/j.medj.2024.07.012. Epub 2024 Aug 23.
Developing countries face an "obesity epidemic," particularly affecting children and younger adults. While obesity is a known risk factor for 12 types of cancer, primarily affecting older populations, its impact on younger generations is understudied.
This study analyzed data from a population-based cancer registry covering 14.14 million individuals in China (2007-2021). We compared the incidence of obesity- and non-obesity-related cancers and applied an age-period-cohort model to estimate their impacts.
Among 651,342 cancer cases, 48.47% were obesity related. The age-standardized incidence rates (ASRs) of the 12 obesity-related cancers increased annually by 3.6% (p < 0.001), while ASRs for non-obesity-related cancers remained stable. Obesity-related cancers surged among younger adults, with rates rising across successive generations. The annual percentage of change decreased with age, from 15.28% for ages 25-29 years to 1.55% for ages 60-64 years. The incidence rate ratio for obesity-related cancer was higher in younger generations compared to those born in 1962-1966. We predict that the ASR for obesity-related cancers will nearly double in the next decade.
The rising incidence of obesity-related cancers among young adults poses a significant public health concern. The increasing cancer burden underscores the need for targeted interventions to address the obesity epidemic.
This work was supported by the National Natural Science Foundation of China (81930019, 82341076) to J.-K.Y.
发展中国家面临着“肥胖症流行”的问题，这尤其影响了儿童和年轻成年人。肥胖症是 12 种癌症的已知风险因素，主要影响老年人群，但它对年轻一代的影响尚未得到充分研究。
本研究分析了中国一个基于人群的癌症登记处的数据，该登记处覆盖了 1414 万人（2007-2021 年）。我们比较了肥胖症相关和非肥胖症相关癌症的发病率，并应用年龄-时期-队列模型来估计它们的影响。
在 651342 例癌症病例中，有 48.47%与肥胖症有关。12 种肥胖症相关癌症的年龄标准化发病率（ASR）每年以 3.6%的速度增长（p<0.001），而非肥胖症相关癌症的 ASR 保持稳定。肥胖症相关癌症在年轻成年人中激增，发病率在连续几代人中上升。随着年龄的增长，每年的变化百分比从 25-29 岁年龄组的 15.28%下降到 60-64 岁年龄组的 1.55%。与出生于 1962-1966 年的人群相比，年轻一代中肥胖症相关癌症的发病率比率更高。我们预测，在未来十年内，肥胖症相关癌症的 ASR 将几乎翻一番。
年轻成年人中肥胖症相关癌症的发病率上升引起了重大的公共卫生关注。不断增加的癌症负担突显出需要采取有针对性的干预措施来应对肥胖症流行。
本工作得到了国家自然科学基金（81930019，82341076）的支持。
