Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, 1163 Xinmin Street, Changchun, Jilin Province, 130021, China.
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, 1163 Xinmin Street, Changchun, Jilin Province, 130021, China.
Environ Pollut. 2024 Nov 15;361:124793. doi: 10.1016/j.envpol.2024.124793. Epub 2024 Aug 23.
Air pollutants have been investigated to be associated with many health issues. Recently, increasing epidemiological studies have suggested the association between air pollution exposure and risk of frailty with inconsistent findings. This systematic review and meta-analysis was to summarize and evaluate effects of exposure to various air pollutants on risk of frailty. PubMed, Embase, Scopus and Web of Science were systematically searched for relevant studies published before May 11, 2024. Studies that explored the potential relationship between exposure to air pollutants (PM, PM, O, NO, solid fuel, secondhand tobacco, and air quality) and risk of frailty were included. The quality of cross-sectional and cohort studies was evaluated using an eight-item assessment instrument for epidemiological studies and Newcastle-Ottawa Scale, respectively. A total of 9,929 papers were retrieved, of which 20 met the inclusion criteria. Meta-analysis indicated that PM exposure was significantly associated with frailty assessed by the frailty index [OR (95% CI): 1.24 (1,11-1.38) per 10 μg/m increment]. Moreover, solid fuel exposures were significantly associated with an increased risk of frailty assessed by the frailty phenotype [OR (95% CI): 1.91 (1.09-3.34)] or the frailty index [OR (95% CI): 1.25 (1.11-1.41)]. Exposure to PM and solid fuel increases the risk of frailty. Environmental protection policies and public health measures should be developed to reduce PM concentrations. Effective measures, such as improving stoves and using clean fuels, should be taken to reduce indoor air pollution levels.
空气污染物已被研究与许多健康问题有关。最近，越来越多的流行病学研究表明，空气污染暴露与衰弱风险之间存在关联，但研究结果不一致。本系统评价和荟萃分析旨在总结和评估暴露于各种空气污染物对衰弱风险的影响。系统地检索了 PubMed、Embase、Scopus 和 Web of Science 中截至 2024 年 5 月 11 日之前发表的相关研究。纳入了探讨暴露于空气污染物（PM、PM、O、NO、固体燃料、二手烟和空气质量）与衰弱风险之间潜在关系的研究。使用流行病学研究八项评估工具和纽卡斯尔-渥太华量表分别评估横断面和队列研究的质量。共检索到 9929 篇论文，其中 20 篇符合纳入标准。荟萃分析表明，PM 暴露与衰弱指数评估的衰弱显著相关[每增加 10μg/m，OR（95%CI）：1.24（1.11-1.38）]。此外，固体燃料暴露与衰弱表型评估的衰弱风险显著相关[OR（95%CI）：1.91（1.09-3.34）]或衰弱指数评估的衰弱风险显著相关[OR（95%CI）：1.25（1.11-1.41）]。PM 和固体燃料的暴露增加了衰弱的风险。应制定环境保护政策和公共卫生措施，以降低 PM 浓度。应采取有效措施，如改进炉灶和使用清洁燃料，以降低室内空气污染水平。
