Department of Gastroenterology and Endoscopy, The First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China.
Department of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China.
Pharmacol Res. 2024 Oct;208:107370. doi: 10.1016/j.phrs.2024.107370. Epub 2024 Aug 22.
Ferroptosis, an emerging paradigm of programmed cellular necrosis posited in recent years, manifests across a spectrum of maladies with profound implications for human well-being. Numerous investigations substantiate that modulating ferroptosis, whether through inhibition or augmentation, plays a pivotal role in the etiology and control of numerous age-related afflictions, encompassing neurological, circulatory, respiratory, and other disorders. This paper not only summarizes the regulatory mechanisms of ferroptosis, but also discusses the impact of ferroptosis on the biological processes of aging and its role in age-related diseases. Furthermore, it scrutinizes recent therapeutic strides in addressing aging-related conditions through the modulation of ferroptosis. The paper consolidates the existing knowledge on potential applications of ferroptosis-related pharmacotherapies and envisages the translational prospects of ferroptosis-targeted interventions in clinical paradigms.
铁死亡，近年来提出的一种新的程序性细胞坏死模式，在多种疾病中表现出来，对人类健康有着深远的影响。大量研究证实，调节铁死亡，无论是通过抑制还是增强，在许多与年龄相关的疾病的病因和控制中都起着关键作用，包括神经、循环、呼吸和其他疾病。本文不仅总结了铁死亡的调控机制，还讨论了铁死亡对衰老生物过程的影响及其在与年龄相关的疾病中的作用。此外，它还研究了通过调节铁死亡来解决与衰老相关的疾病的最新治疗进展。本文整合了关于铁死亡相关药物治疗潜在应用的现有知识，并设想了铁死亡靶向干预在临床范例中的转化前景。
