Hong Longyan, Chen Xiangyu, Liu Yiming, Liang Hao, Zhao Yinghui, Guo Pengbo
Department of Pathogen Biology, School of Clinical and Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
The First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Front Immunol. 2025 Mar 18;16:1550968. doi: 10.3389/fimmu.2025.1550968. eCollection 2025.
Respiratory infectious diseases, particularly those caused by respiratory viruses, have the potential to lead to global pandemics, thereby posing significant threats to public and human health. Historically, the primary treatment for respiratory bacterial infections has been antibiotic therapy, while severe cases of respiratory viral infections have predominantly been managed by controlling inflammatory cytokine storms. Ferroptosis is a novel form of programmed cell death that is distinct from apoptosis and autophagy. In recent years, Recent studies have demonstrated that ferroptosis plays a significant regulatory role in various respiratory infectious diseases, indicating that targeting ferroptosis may represent a novel approach for the treatment of these conditions. This article summarized the toxic mechanisms underlying ferroptosis, its relationship with respiratory infectious diseases, the mechanisms of action, and current treatment strategies. Particular attentions were given to the interplay between ferroptosis and Mycobacterium tuberculosis, Epstein-Barr virus, severe acute respiratory syndrome coronavirus-2, Pseudomonas aeruginosa, dengue virus, influenza virus and herpes simplex virus type1infection. A deeper understanding of the regulatory mechanisms of ferroptosis in respiratory infections will not only advance our knowledge of infection-related pathophysiology but also provide a theoretical foundation for the development of novel therapeutic strategies. Targeting ferroptosis pathways represents a promising therapeutic approach for respiratory infections, with significant clinical and translational implications.
呼吸道感染性疾病，尤其是由呼吸道病毒引起的疾病，有可能引发全球大流行，从而对公众和人类健康构成重大威胁。从历史上看，呼吸道细菌感染的主要治疗方法是抗生素治疗，而严重的呼吸道病毒感染病例主要通过控制炎症细胞因子风暴来处理。铁死亡是一种新型的程序性细胞死亡形式，不同于凋亡和自噬。近年来，研究表明铁死亡在各种呼吸道感染性疾病中发挥着重要的调节作用，这表明靶向铁死亡可能代表一种治疗这些疾病的新方法。本文总结了铁死亡的毒性机制、其与呼吸道感染性疾病的关系、作用机制以及当前的治疗策略。特别关注了铁死亡与结核分枝杆菌、爱泼斯坦-巴尔病毒、严重急性呼吸综合征冠状病毒2、铜绿假单胞菌、登革病毒、流感病毒和单纯疱疹病毒1型感染之间的相互作用。深入了解铁死亡在呼吸道感染中的调节机制不仅将推进我们对感染相关病理生理学的认识，还将为开发新的治疗策略提供理论基础。靶向铁死亡途径代表了一种有前途的呼吸道感染治疗方法，具有重要的临床和转化意义。
