Bernstein M L, Neal D C
J Oral Pathol. 1985 Jan;14(1):8-14. doi: 10.1111/j.1600-0714.1985.tb00460.x.
Calcinosis, the process whereby calcium salts are deposited in soft tissues, may be idiopathic, metastatic or dystrophic. Metastatic calcinosis develops in a variety of systemic diseases characterized by either hypercalcemia, hyperphosphatemia, or both. Dystrophic calcinosis refers to calcification of previously damaged or necrotic tissue. It may be found accompanying inflammatory or degenerative conditions and is frequently associated with connective tissue diseases. When pathologic calcification is widespread, an attempt must be made to determine the underlying cause. A case is presented in which there was multifocal calcium deposition in soft tissues, including an intra-oral site. The patient also exhibited severe arthritis, sicca syndrome, focal alopecia and vitiligo. In view of this clinical spectrum, one of the "collagen diseases" (dermatomyositis, lupus erythematosus, rheumatoid arthritis, and scleroderma) was suspected as a predisposing factor for disseminated calcinosis. When diagnostic workup failed to reveal a specific connective tissue disease, it was concluded that "undifferentiated connective tissue disease" was responsible for dystrophic calcinosis.
钙质沉着症是指钙盐沉积于软组织的过程，可分为特发性、转移性或营养不良性。转移性钙质沉着症在多种以高钙血症、高磷血症或两者兼具为特征的全身性疾病中发生。营养不良性钙质沉着症是指先前受损或坏死组织的钙化。它可能伴随炎症或退行性疾病出现，且常与结缔组织疾病相关。当病理性钙化广泛存在时，必须努力确定其潜在病因。现报告一例软组织多处钙沉积的病例，其中包括口腔内一处。该患者还表现出严重关节炎、干燥综合征、局限性脱发和白癜风。鉴于此临床症状，怀疑“胶原病”（皮肌炎、红斑狼疮、类风湿关节炎和硬皮病）之一是播散性钙质沉着症的诱发因素。当诊断检查未能发现特定的结缔组织疾病时，得出结论认为“未分化结缔组织病”是营养不良性钙质沉着症的病因。
