School of Science, Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen, 518055, China.
School of Biomedical Engineering, Medical School, Shenzhen University, Shenzhen, 518060, Guangdong, China.
J Nanobiotechnology. 2024 Aug 24;22(1):510. doi: 10.1186/s12951-024-02786-w.
Cancer is measured as a major threat to human life and is a leading cause of death. Millions of cancer patients die every year, although a burgeoning number of researchers have been making tremendous efforts to develop cancer medicine to fight against cancer. Owing to the complexity and heterogeneity of cancer, lack of ability to treat deep tumor tissues, and high toxicity to the normal cells, it complicates the therapy of cancer. However, bacterial derivative-mediated drug delivery has raised the interest of researchers in overcoming the restrictions of conventional cancer chemotherapy. In this review, we show various examples of tumor-targeting bacteria and bacterial derivatives for the delivery of anticancer drugs. This review also describes the advantages and limitations of delivering anticancer treatment drugs under regulated conditions employing these tumor-targeting bacteria and their membrane vesicles. This study highlights the substantial potential for clinical translation of bacterial-based drug carriers, improve their ability to work with other treatment modalities, and provide a more powerful, dependable, and distinctive tumor therapy.
癌症被视为对人类生命的重大威胁，是主要的死亡原因之一。尽管每年都有大量的癌症患者死亡，但数以百万计的研究人员正在不懈努力开发癌症药物以对抗癌症。由于癌症的复杂性和异质性、缺乏对深层肿瘤组织的治疗能力以及对正常细胞的高毒性，这使得癌症的治疗变得复杂。然而，细菌衍生介导的药物输送引起了研究人员的兴趣，以克服传统癌症化疗的限制。在这篇综述中，我们展示了各种用于输送抗癌药物的肿瘤靶向细菌和细菌衍生物的例子。本综述还描述了在调节条件下使用这些肿瘤靶向细菌及其膜泡输送抗癌治疗药物的优势和局限性。这项研究强调了基于细菌的药物载体具有很大的临床转化潜力，提高了它们与其他治疗方式结合的能力，并为肿瘤治疗提供了更强大、更可靠和更独特的方法。
