冻融胚胎移植与儿童过敏的关联：一项回顾性队列研究。
Association between frozen embryo transfer and childhood allergy: a retrospective cohort study.
机构信息
Key Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
出版信息
Reprod Biomed Online. 2024 Nov;49(5):104320. doi: 10.1016/j.rbmo.2024.104320. Epub 2024 Jun 9.
RESEARCH QUESTION
Does frozen embryo transfer (FET) increase the risk of allergic diseases in offspring?
DESIGN
This study followed up 653 singleton children: 166 born through FET and 487 born through natural conception. Demographic characteristics, perinatal information and allergic diseases of children and their parents were collected through clinical medical systems and questionnaires. Among these 653 children, allergen-specific immunoglobulin E (IgE) testing was performed using peripheral blood samples collected from 207 children: 145 in the FET group and 62 in the natural conception group. The prevalence of allergic diseases and positive rates of allergen-specific IgE testing were compared between the two groups with adjustments for confounding factors.
RESULTS
The prevalence of food allergy was significantly higher in children born through FET compared with children born through natural conception (adjusted OR = 3.154, 95% CI 1.895-5.250; P < 0.001). In addition, positive rates of food allergen sensitization were higher in children in the FET group compared with children in the natural conception group (adjusted OR = 5.769, 95% CI 2.859-11.751, P < 0.001). Children in the FET group had a higher positive sensitization rate to at least one allergen compared with children in the natural conception group (adjusted OR = 3.127, 95% CI 1.640-5.961, P < 0.001). No association was observed between FET and other allergic diseases, including asthma (P = 0.136), atopic dermatitis (P = 0.130) and allergic rhinitis (P = 0.922). Allergen sensitization IgE testing indicated no differences between the two groups in terms of positive sensitization rates of other common allergens, including animal and insect allergens (P = 0.627), inhaled outdoor allergens (P = 0.915) and inhaled outdoor allergens (P = 0.544).
CONCLUSION
This study suggests that children born through FET have increased risk of developing food allergy in early childhood.
研究问题
冻融胚胎移植（FET）是否会增加后代患过敏性疾病的风险？
设计
本研究随访了 653 名单胎儿童：166 名通过 FET 出生，487 名通过自然受孕出生。通过临床医疗系统和问卷调查收集了儿童及其父母的人口统计学特征、围产期信息和过敏性疾病。在这 653 名儿童中，207 名儿童进行了外周血过敏原特异性免疫球蛋白 E（IgE）检测：FET 组 145 名，自然受孕组 62 名。调整混杂因素后，比较两组儿童过敏性疾病的患病率和过敏原特异性 IgE 检测阳性率。
结果
与自然受孕出生的儿童相比，FET 出生的儿童食物过敏的患病率显著更高（校正比值比 = 3.154，95%置信区间 1.895-5.250；P < 0.001）。此外，FET 组儿童食物过敏原致敏的阳性率高于自然受孕组（校正比值比 = 5.769，95%置信区间 2.859-11.751，P < 0.001）。与自然受孕组相比，FET 组儿童至少有一种过敏原的阳性致敏率更高（校正比值比 = 3.127，95%置信区间 1.640-5.961，P < 0.001）。FET 与其他过敏性疾病（包括哮喘、特应性皮炎和过敏性鼻炎）之间无关联（P = 0.136、P = 0.130 和 P = 0.922）。过敏原致敏 IgE 检测表明，两组常见过敏原（动物和昆虫过敏原、吸入性室外过敏原和吸入性室内过敏原）的阳性致敏率无差异（P = 0.627、P = 0.915 和 P = 0.544）。
结论
本研究表明，FET 出生的儿童在幼儿期患食物过敏的风险增加。
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