Reproductive Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
Zhejiang Provincial Clinical Research Center for Obstetrics and Gynecology, Hangzhou 310016, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2024 Aug 25;53(4):527-530. doi: 10.3724/zdxbyxb-2023-0561.
A 15-year-old female with Hodgkin's lymphoma underwent ovarian tissue cryopreservation for preserving fertility in Reproductive Department of Sir Run Run Shaw Hospital, Zhejiang University School of Medical after receiving one course of chemotherapy. During the ovarian tissue cryopreservation, one MⅡmature oocyte and three germinal vesicle oocytes were found. The three immature oocytes underwent maturation but failed. Ultimately, one mature oocyte and 12 ovarian cortex slices were cryopreserved using vitrification. This case indicates that for patients with established gonadal axis feedback, ovarian tissue cryopreservation may not be the only method for fertility preservation. It is advisable to consider ovarian stimulation and oocyte retrieval for oocyte cryopreservation. Alternatively, for individuals in the ovulation phase of their menstrual cycle, attempting oocyte retrieval before ovarian tissue cryopreservation to obtain mature oocytes from the natural cycle, followed by oocyte cryopreservation, may enhance the likelihood of successful fertility preservation.
一位 15 岁的女性霍奇金淋巴瘤患者在接受一个疗程的化疗后，前往浙江大学医学院附属邵逸夫医院生殖医学科进行卵巢组织冷冻保存以保留生育能力。在卵巢组织冷冻保存过程中，发现一枚 MⅡ期成熟卵母细胞和三枚生发泡期卵母细胞。这三个不成熟的卵母细胞经历了成熟过程，但都失败了。最终，使用玻璃化法冷冻保存了一枚成熟卵母细胞和 12 个卵巢皮质切片。本病例表明，对于已经建立性腺轴反馈的患者，卵巢组织冷冻保存可能不是唯一的生育力保存方法。建议考虑卵巢刺激和卵母细胞采集进行卵母细胞冷冻保存。或者，对于处于月经周期排卵阶段的个体，可以在卵巢组织冷冻保存之前尝试卵母细胞采集，从自然周期中获得成熟卵母细胞，然后进行卵母细胞冷冻保存，这可能会提高成功进行生育力保存的可能性。
