肌动蛋白结合蛋白纽蛋白、细丝蛋白和纤连蛋白在心肌细胞内和细胞间连接中的作用。

The role of actin-binding proteins vinculin, filamin, and fibronectin in intracellular and intercellular linkages in cardiac muscle.

作者信息

Koteliansky V E, Shirinsky V P, Gneushev G N, Chernousov M A

出版信息

Adv Myocardiol. 1985;5:215-21. doi: 10.1007/978-1-4757-1287-2_17.

Abstract

The localization in cardiac muscle and the biochemical properties of fibronectin, filamin, and vinculin were studied. Fibronectin was localized between cardiomyocytes. Filamin was identified in the Z-line region of sarcomers and in the intercalated disks of heart muscle. Vinculin was found to be present in intercalated disks and near the plasma membrane at the cell periphery between external myofibrils and sarcolemma. It was suggested that fibronectin, filamin, and vinculin play an important role in intercellular and intracellular linkages in cardiac muscle.

摘要

研究了纤连蛋白、细丝蛋白和纽蛋白在心肌中的定位及其生化特性。纤连蛋白定位于心肌细胞之间。细丝蛋白在肌节的Z线区域和心肌的闰盘中被鉴定出来。发现纽蛋白存在于闰盘中以及外部肌原纤维和肌膜之间细胞周边的质膜附近。有人提出，纤连蛋白、细丝蛋白和纽蛋白在心肌的细胞间和细胞内连接中起重要作用。