Arkansas Children's Nutrition Center, Little Rock, Arkansas, USA.
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Pediatr Obes. 2024 Dec;19(12):e13162. doi: 10.1111/ijpo.13162. Epub 2024 Aug 25.
Clustering of cardiometabolic risk factors in childhood significantly increases the risk of atherosclerotic cardiovascular disease later in life. Identification of modifiable parental factors that contribute to offspring cardiometabolic health is critical for the prevention of disease. The objective was to identify factors associated with child cardiometabolic risk factors at age 5 years.
Triads from a longitudinal cohort were recalled at 5 years (n = 68). Dietary intake, anthropometrics, physical activity and serum-based risk factors were collected. Best subset selection, linear and logistic regressions were used to identify triad variables associated with increased risk of cardiometabolic risk factor clustering at age 5 years.
In this cohort, best subset modelling revealed that increased paternal fat mass, serum low-density lipoproteins and triglycerides, maternal dietary added sugar and being female were associated with increased odds of offspring having two or more cardiometabolic risk factors at age 5 years.
Dietary and exercise interventions prior to conception targeting paternal adiposity and dyslipidaemia as well as maternal dietary habits could decrease children's cardiometabolic risk in later life.
儿童时期心血管代谢危险因素的聚集显著增加了日后发生动脉粥样硬化性心血管疾病的风险。确定可改变的父母因素对后代心血管代谢健康的影响对于疾病预防至关重要。本研究旨在确定与 5 岁儿童心血管代谢危险因素相关的因素。
对纵向队列中的三胞胎在 5 岁时进行了召回（n=68）。收集了饮食摄入、人体测量学、身体活动和基于血清的危险因素。最佳子集选择、线性和逻辑回归用于确定与 5 岁时心血管代谢危险因素聚集风险增加相关的三胞胎变量。
在该队列中，最佳子集模型显示，父亲体脂肪增加、血清低密度脂蛋白和甘油三酯、母亲饮食添加糖和女性与后代在 5 岁时出现两种或多种心血管代谢危险因素的几率增加有关。
在受孕前针对父亲肥胖和血脂异常以及母亲饮食习惯进行饮食和运动干预，可能会降低孩子日后的心血管代谢风险。
