Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
State Key Laboratory of Respiratory Health and Multimorbidity, Chengdu, China.
Ann Med. 2024 Dec;56(1):2390200. doi: 10.1080/07853890.2024.2390200. Epub 2024 Aug 26.
Lung cancer has maintained a high prevalence and mortality. Besides, venous thromboembolism (VTE) is the third most common disease of cardiovascular disease. Lung cancer with VTE usually influenced the overall survival in the follow-up. In the development of lung cancer, vigilance against and early diagnosis of VTE is of significance.
We searched the databases of PubMed, Web of Science, Embase and Cochrane for related research up to 30 November 2023 and extracted information of incidence, odds ratio (OR), hazard ratio (HR) and their 95% confidence intervals (CIs), for evaluating the incidence of VTE and its risk factors.
A total of 54 articles and 873,292 records were included in our study. The pooled incidences of VTE and PE were 6% and 3%, respectively. Subgroup analysis revealed that the tumour, node and metastasis (TNM) stage (HR= 5.43, 95% CI: 2.42, 12.22), metastasis (HR= 2.67, 95% CI: 1.35, 5.29) and chemotherapy (HR= 2.27, 95% CI: 1.11, 4.65) had major influence on VTE occurrence.
Lung cancer complicated with VTE is unignorable, and its occurrence varies widely by tumour staging, tissue type and treatment. The results may aid in clinical decision-making about lung cancer in higher risk with VTE and weather receiving anticoagulant prophylaxis.
肺癌的发病率和死亡率一直居高不下。此外，静脉血栓栓塞症（VTE）是心血管疾病的第三大常见疾病。肺癌合并 VTE 通常会影响患者的总体生存。在肺癌的发展过程中，警惕和早期诊断 VTE 具有重要意义。
我们检索了 PubMed、Web of Science、Embase 和 Cochrane 数据库，截至 2023 年 11 月 30 日，提取了发病率、优势比（OR）、风险比（HR）及其 95%置信区间（CI）的相关研究信息，以评估 VTE 的发病率及其危险因素。
共纳入 54 篇文章和 873292 条记录。VTE 和 PE 的总发病率分别为 6%和 3%。亚组分析显示，肿瘤、淋巴结和转移（TNM）分期（HR=5.43，95%CI：2.42，12.22）、转移（HR=2.67，95%CI：1.35，5.29）和化疗（HR=2.27，95%CI：1.11，4.65）对 VTE 的发生有重大影响。
肺癌合并 VTE 不容忽视，其发生与肿瘤分期、组织类型和治疗方法有关。这些结果可能有助于临床对 VTE 风险较高的肺癌患者做出决策，是否接受抗凝预防。
