Raichlen David A, Ally Madeline, Aslan Daniel H, Sayre M Katherine, Bharadwaj Pradyumna K, Maltagliati Silvio, Lai Mark H C, Wilcox Rand R, Habeck Christian G, Klimentidis Yann C, Alexander Gene E
Human and Evolutionary Biology Section Department of Biological Sciences University of Southern California Los Angeles California USA.
Department of Anthropology University of Southern California Los Angeles California USA.
Alzheimers Dement (Amst). 2024 Aug 23;16(3):e70001. doi: 10.1002/dad2.70001. eCollection 2024 Jul-Sep.
We examined the relationship between sedentary behavior (SB), moderate-to-vigorous physical activity (MVPA), and white matter hyperintensity (WMH) volumes, a common magnetic resonance imaging (MRI) marker associated with risk of neurodegenerative disease in middle-aged to older adults.
We used data from the UK Biobank ( = 14,415; 45 to 81 years) that included accelerometer-derived measures of SB and MVPA, and WMH volumes from MRI.
Both MVPA and SB were associated with WMH volumes (β= -0.03 [-0.04, -0.01], < 0.001; β= 0.02 [0.01, 0.03], = 0.007). There was a significant interaction between SB and MVPA on WMH volumes (β= -0.015 [-0.028, -0.001], = 0.03) where SB was positively associated with WMHs at low MVPA, and MVPA was negatively associated with WMHs at high SB.
While this study cannot establish causality, the results highlight the potential importance of considering both MVPA and SB in strategies aimed at reducing the accumulation of WMH volumes in middle-aged to older adults.
SB is associated with greater WMH volumes and MVPA is associated with lower WMH volumes.Relationships between SB and WMH are strongest at low levels of MVPA.Associations between MVPA and WMH are strongest at high levels of SB.Considering both SB and MVPA may be effective strategies for reducing WMHs.
我们研究了久坐行为（SB）、中度至剧烈身体活动（MVPA）与白质高信号（WMH）体积之间的关系，WMH是一种常见的磁共振成像（MRI）标志物，与中老年人群神经退行性疾病风险相关。
我们使用了英国生物银行的数据（n = 14415；年龄45至81岁），其中包括通过加速度计得出的SB和MVPA测量值，以及MRI测得的WMH体积。
MVPA和SB均与WMH体积相关（β = -0.03 [-0.04, -0.01]，P < 0.001；β = 0.02 [0.01, 0.03]，P = 0.007）。SB和MVPA对WMH体积存在显著交互作用（β = -0.015 [-0.028, -0.001]，P = 0.03），即低MVPA时SB与WMH呈正相关，高SB时MVPA与WMH呈负相关。
虽然本研究无法确定因果关系，但结果凸显了在旨在减少中老年人群WMH体积积累的策略中同时考虑MVPA和SB的潜在重要性。
SB与更大的WMH体积相关，MVPA与更小的WMH体积相关。MVPA水平较低时，SB与WMH的关系最强。SB水平较高时，MVPA与WMH的关联最强。同时考虑SB和MVPA可能是减少WMH的有效策略。
