University of British Columbia, Faculty of Medicine, Aging, Mobility and Cognitive Neuroscience Laboratory, Djavad Mowafaghian Centre for Brain Health, Vancouver Coastal Health Research Institute, Vancouver, BC, CANADA.
University of British Columbia, Faculty of Medicine, Arthritis Research Canada, Vancouver, BC, CANADA.
Med Sci Sports Exerc. 2020 Oct;52(10):2217-2223. doi: 10.1249/MSS.0000000000002374.
Cortical thinning is associated with aging; however, lifestyle factors can moderate this relationship. Two distinct lifestyle behaviors associated with brain health are regular moderate-to-vigorous physical activity (MVPA) and limited sedentary behavior (SB). However, it is unclear whether MVPA and SB levels contribute to cortical thickness independent of each other. We therefore investigated the independent relationships of MVPA and SB with cortical thickness using baseline data from a randomized controlled trial.
At baseline, we measured MVPA and SB for 7 d using the SenseWear Mini. A subset of the randomized controlled trial participants (n = 30) underwent a 3T magnetic resonance imaging scan, wherein region-specific cortical surface morphometric analyses were performed using T1-weighted structural magnetic resonance imaging. We conducted regression analyses using a surface-based cluster size exclusion method for multiple comparisons within FreeSurfer neuroimaging software to determine if MVPA and SB are independently correlated with region-specific cortical thickness.
This subset of participants had a mean age of 61 yr (SD = 9 yr), and 80% were female. Higher MVPA was associated with greater cortical thickness in the temporal pole (cluster size, 855 mm; cortical thickness range, 2.59-3.72 mm; P < 0.05) and superior frontal gyrus (cluster size, 1204 mm; cortical thickness range, 2.41-3.15 mm; P < 0.05) of the left hemisphere, independent of SB. Sedentary behavior was not associated with greater cortical thickness in any region, independent of MVPA.
Our results indicate that adults with greater MVPA-independent of SB-are associated with greater cortical thickness in regions, which are susceptible to age-associated atrophy.
皮质变薄与衰老有关；然而，生活方式因素可以调节这种关系。与大脑健康相关的两种截然不同的生活方式行为是有规律的中等至剧烈强度的身体活动（MVPA）和有限的久坐行为（SB）。然而，目前尚不清楚 MVPA 和 SB 水平是否独立于彼此而与皮质厚度有关。因此，我们使用一项随机对照试验的基线数据，研究了 MVPA 和 SB 与皮质厚度的独立关系。
在基线时，我们使用 SenseWear Mini 测量了 7 天的 MVPA 和 SB。随机对照试验的一部分参与者（n = 30）接受了 3T 磁共振成像扫描，其中使用 T1 加权结构磁共振成像对特定区域的皮质表面形态测量分析进行了分析。我们在 FreeSurfer 神经影像学软件中使用基于表面的聚类大小排除方法进行回归分析，以确定 MVPA 和 SB 是否与特定区域的皮质厚度独立相关。
该参与者子集的平均年龄为 61 岁（SD = 9 岁），80%为女性。较高的 MVPA 与左侧颞极（聚类大小，855mm；皮质厚度范围，2.59-3.72mm；P < 0.05）和额上回（聚类大小，1204mm；皮质厚度范围，2.41-3.15mm；P < 0.05）的皮质厚度更大相关，独立于 SB。久坐行为与任何区域的皮质厚度增加均无关，与 MVPA 无关。
我们的研究结果表明，与 SB 无关的 MVPA 较高的成年人与易受年龄相关萎缩影响的区域的皮质厚度增加有关。
