• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

当平均水平还不够好时:识别临床数据中有意义的亚组。

When Average Isn't Good Enough: Identifying Meaningful Subgroups in Clinical Data.

作者信息

Gloster Andrew T, Nadler Matthias, Block Victoria, Haller Elisa, Rubel Julian, Benoy Charles, Villanueva Jeanette, Bader Klaus, Walter Marc, Lang Undine, Hofmann Stefan G, Ciarrochi Joseph, Hayes Steven C

机构信息

Division of Clinical Psychology and Intervention Science, Department of Psychology, University of Basel, Basel, Switzerland.

Center for Innovative Finance, University of Basel, Basel, Switzerland.

出版信息

Cognit Ther Res. 2024;48(4):537-551. doi: 10.1007/s10608-023-10453-x. Epub 2024 Jan 28.

DOI:10.1007/s10608-023-10453-x
PMID:39184307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11341641/
Abstract

BACKGROUND

Clinical data are usually analyzed with the assumption that knowledge gathered from group averages applies to the individual. Doing so potentially obscures patients with meaningfully different trajectories of therapeutic change. Needed are "idionomic" methods that first examine idiographic patterns before nomothetic generalizations are made. The objective of this paper is to test whether such an idionomic method leads to different clinical conclusions.

METHODS

51 patients completed weekly process measures and symptom severity over a period of eight weeks. Change trajectories were analyzed using a nomothetic approach and an idiographic approach with bottom-up clustering of similar individuals. The outcome was patients' well-being at post-treatment.

RESULTS

Individuals differed in the extent that underlying processes were linked to symptoms. Average trend lines did not represent the intraindividual changes well. The idionomic approach readily identified subgroups of patients that differentially predicted distal outcomes (well-being).

CONCLUSIONS

Relying exclusively on average results may lead to an oversight of intraindividual pathways. Characterizing data first using idiographic approaches led to more refined conclusions, which is clinically useful, scientifically rigorous, and may help advance individualized psychotherapy approaches.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1007/s10608-023-10453-x.

摘要

背景

临床数据的分析通常基于这样的假设,即从群体平均值中获得的知识适用于个体。这样做可能会掩盖治疗变化轨迹有显著差异的患者。需要“独特法则”方法,即在进行通则性概括之前先检查独特模式。本文的目的是测试这种独特法则方法是否会得出不同的临床结论。

方法

51名患者在八周时间内完成了每周的过程测量和症状严重程度评估。使用通则性方法和独特性方法(对相似个体进行自下而上聚类)分析变化轨迹。结果是治疗后的患者幸福感。

结果

个体在潜在过程与症状的关联程度上存在差异。平均趋势线不能很好地代表个体内部的变化。独特法则方法很容易识别出对远期结果(幸福感)有不同预测的患者亚组。

结论

仅依赖平均结果可能会忽略个体内部的路径。首先使用独特性方法对数据进行特征描述会得出更精确的结论,这在临床上有用,在科学上严谨,并且可能有助于推进个体化心理治疗方法。

补充信息

在线版本包含可在10.1007/s10608-023-10453-x获取的补充材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f1/11341641/a6d61ebbfd42/10608_2023_10453_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f1/11341641/6ee24d1fec2f/10608_2023_10453_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f1/11341641/8d4e888aa9e3/10608_2023_10453_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f1/11341641/fd5c81c70de0/10608_2023_10453_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f1/11341641/9a105d5bc51c/10608_2023_10453_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f1/11341641/cbbb8e235a0d/10608_2023_10453_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f1/11341641/90c28fc99c21/10608_2023_10453_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f1/11341641/a6d61ebbfd42/10608_2023_10453_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f1/11341641/6ee24d1fec2f/10608_2023_10453_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f1/11341641/8d4e888aa9e3/10608_2023_10453_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f1/11341641/fd5c81c70de0/10608_2023_10453_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f1/11341641/9a105d5bc51c/10608_2023_10453_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f1/11341641/cbbb8e235a0d/10608_2023_10453_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f1/11341641/90c28fc99c21/10608_2023_10453_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f1/11341641/a6d61ebbfd42/10608_2023_10453_Fig7_HTML.jpg

相似文献

1
When Average Isn't Good Enough: Identifying Meaningful Subgroups in Clinical Data.当平均水平还不够好时:识别临床数据中有意义的亚组。
Cognit Ther Res. 2024;48(4):537-551. doi: 10.1007/s10608-023-10453-x. Epub 2024 Jan 28.
2
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.在流行地区,服用抗叶酸抗疟药物的人群中,叶酸补充剂与疟疾易感性和严重程度的关系。
Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217.
3
Evolving an idionomic approach to processes of change: Towards a unified personalized science of human improvement.发展一种针对变化过程的独特方法:迈向统一的人类进步个性化科学。
Behav Res Ther. 2022 Sep;156:104155. doi: 10.1016/j.brat.2022.104155. Epub 2022 Jul 3.
4
The future of Cochrane Neonatal.考克兰新生儿协作网的未来。
Early Hum Dev. 2020 Nov;150:105191. doi: 10.1016/j.earlhumdev.2020.105191. Epub 2020 Sep 12.
5
Bridging the Nomothetic and Idiographic Approaches to the Analysis of Clinical Data.弥合临床数据分析中通则法与个案法之间的差距。
Assessment. 2016 Aug;23(4):447-458. doi: 10.1177/1073191116648209.
6
Assessing current concerns and goals idiographically: A review of the Motivational Structure Questionnaire family of instruments.从独特视角评估当前关注的问题和目标:对动机结构问卷系列工具的综述。
J Clin Psychol. 2023 Mar;79(3):667-682. doi: 10.1002/jclp.23256. Epub 2021 Oct 2.
7
Nomothetic and idiographic symptom change trajectories in acute-phase cognitive therapy for recurrent depression.在复发性抑郁症的急性期认知治疗中,共变和特质症状变化轨迹。
J Consult Clin Psychol. 2013 Aug;81(4):615-26. doi: 10.1037/a0032879. Epub 2013 Apr 29.
8
Rigorous idiography: Exploring subjective and idiographic data with rigorous methods-The method of derangements.严谨的个案研究法:用严谨的方法探索主观和个案数据——错排法
Front Psychol. 2023 Jan 11;13:1007685. doi: 10.3389/fpsyg.2022.1007685. eCollection 2022.
9
Foundations of idiographic methods in psychology and applications for psychotherapy.心理学中个性化方法的基础及其在心理治疗中的应用
Clin Psychol Rev. 2019 Jul;71:90-100. doi: 10.1016/j.cpr.2019.01.002. Epub 2019 Jan 14.
10
Intentional research design in implementation science: implications for the use of nomothetic and idiographic assessment.实施科学中的意向性研究设计:对使用通则性和独特性评估的启示。
Transl Behav Med. 2017 Sep;7(3):567-580. doi: 10.1007/s13142-017-0464-6.

引用本文的文献

1
The role of psychological flexibility in relation to health outcomes in people in remission from cancer.心理灵活性在癌症缓解期患者健康状况方面的作用。
Br J Health Psychol. 2025 Sep;30(3):e12807. doi: 10.1111/bjhp.12807.
2
How to personalise cognitive-behavioural therapy for chronic primary pain using network analysis: study protocol for a single-case experimental design with multiple baselines.如何使用网络分析为慢性原发性疼痛个性化定制认知行为疗法:一项具有多个基线的单病例实验设计的研究方案
BMJ Open. 2024 Dec 3;14(12):e089319. doi: 10.1136/bmjopen-2024-089319.

本文引用的文献

1
Psychotherapy for Chronic In- and Outpatients with Common Mental Disorders: The "Choose Change" Effectiveness Trial.常见精神障碍的慢性住院和门诊患者的心理治疗:“选择改变”有效性试验。
Psychother Psychosom. 2023;92(2):124-132. doi: 10.1159/000529411. Epub 2023 Apr 6.
2
"Third-wave" cognitive and behavioral therapies and the emergence of a process-based approach to intervention in psychiatry.“第三波”认知行为疗法与基于过程的精神病学干预方法的出现。
World Psychiatry. 2021 Oct;20(3):363-375. doi: 10.1002/wps.20884.
3
A process-based approach to psychological diagnosis and treatment:The conceptual and treatment utility of an extended evolutionary meta model.
基于过程的心理诊断与治疗方法:扩展进化元模型的概念和治疗效用。
Clin Psychol Rev. 2020 Dec;82:101908. doi: 10.1016/j.cpr.2020.101908. Epub 2020 Sep 7.
4
Treating treatment non-responders: A meta-analysis of randomized controlled psychotherapy trials.治疗治疗无反应者:随机对照心理治疗试验的荟萃分析。
Clin Psychol Rev. 2020 Feb;75:101810. doi: 10.1016/j.cpr.2019.101810. Epub 2019 Dec 19.
5
"Choose change": design and methods of an acceptance and commitment therapy effectiveness trial for transdiagnostic treatment-resistant patients.“选择改变”:针对跨诊断治疗抵抗患者的接受与承诺疗法有效性试验的设计和方法。
BMC Psychiatry. 2019 Jun 10;19(1):173. doi: 10.1186/s12888-019-2109-4.
6
Non-Gaussian, non-ergodic, and non-Fickian diffusion of tracers in mucin hydrogels.示踪剂在粘蛋白水凝胶中的非高斯、非遍历和非菲克扩散。
Soft Matter. 2019 Mar 20;15(12):2526-2551. doi: 10.1039/c8sm02096e.
7
The Future of Intervention Science: Process-Based Therapy.干预科学的未来:基于过程的疗法。
Clin Psychol Sci. 2019 Jan;7(1):37-50. doi: 10.1177/2167702618772296. Epub 2018 May 29.
8
The role of the individual in the coming era of process-based therapy.个体在基于流程的治疗时代的作用。
Behav Res Ther. 2019 Jun;117:40-53. doi: 10.1016/j.brat.2018.10.005. Epub 2018 Oct 16.
9
Lack of group-to-individual generalizability is a threat to human subjects research.群体到个体的泛化不足是对人类受试者研究的一种威胁。
Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6106-E6115. doi: 10.1073/pnas.1711978115. Epub 2018 Jun 18.
10
Increasing valued behaviors precedes reduction in suffering: Findings from a randomized controlled trial using ACT.增加有价值的行为先于减少痛苦:使用 ACT 的随机对照试验结果。
Behav Res Ther. 2017 Apr;91:64-71. doi: 10.1016/j.brat.2017.01.013. Epub 2017 Jan 24.