Datarkar Abhay, Bhawalkar Amit, Shah Vartik, Manekar Varsha, Gadve Vandana, Daware Surendra, Walkey Damyanti, Gioia Francesca, Acero Julio
Department of Oral and Maxillofacial Surgery, Government Dental College and Hospital, Government Medical College Premises, Nagpur, Maharashtra, India.
Department of Infectious Disease, University Hospital Ramon y Cajal, IRYCIS and CIBER, Madrid, Spain.
Ann Maxillofac Surg. 2024 Jan-Jun;14(1):40-45. doi: 10.4103/ams.ams_16_24. Epub 2024 Jul 19.
The objective of the study was to describe the incidence, clinical characteristics, treatment and outcome of patients with rhinocerebral coronavirus disease 2019-associated mucormycosis (CAM).
We performed an unicentric observational study. A total of 113 cases of CAM were evaluated from January 2021 to June 2021. We described the overall incidence of CAM in Nagpur district up to June 2021, the clinical presentation of CAM, the subtype of CAM, the laboratory diagnosis, the type of surgical management in CAM, the pre-operative and 3-month post-operative C-reactive protein marker values, the post-operative healing and complications and the mortality rate.
The mean age of the patients was 38.8 years. Rhinomaxillary subtype was the most common. All patients underwent medical as well as surgical intervention as the treatment modality. There was mortality in two patients.
Study highlights the need for physicians to closely monitor coronavirus disease 2019 (COVID-19) patients, especially severe cases with pre-existing diabetes/receiving corticosteroid therapy and the need for patient education as early diagnosis and prompt treatment leads to better prognosis.
本研究的目的是描述2019冠状病毒病相关鼻脑型毛霉菌病（CAM）患者的发病率、临床特征、治疗及预后情况。
我们开展了一项单中心观察性研究。对2021年1月至2021年6月期间的113例CAM病例进行了评估。我们描述了截至2021年6月那格浦尔地区CAM的总体发病率、CAM的临床表现、CAM的亚型、实验室诊断、CAM的手术治疗方式、术前及术后3个月的C反应蛋白标志物值、术后愈合情况及并发症以及死亡率。
患者的平均年龄为38.8岁。鼻上颌窦亚型最为常见。所有患者均接受了药物及手术干预作为治疗方式。有2例患者死亡。
研究强调医生需要密切监测2019冠状病毒病（COVID-19）患者，尤其是患有糖尿病/正在接受皮质类固醇治疗的重症病例，以及患者教育的必要性，因为早期诊断和及时治疗可带来更好的预后。
