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一例急性双草醚钠人体中毒表现为乳酸性酸中毒的病例

A Case of Acute Human Self-Poisoning With Bispyribac Sodium Presenting as Lactic Acidosis.

作者信息

Jayachandran Sreejith, Kaeley Nidhi, Sasidharan Parvathy, Mathew Joen R, Paul Amrita

机构信息

Emergency Medicine, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.

Family and Community Medicine, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.

出版信息

Cureus. 2024 Jul 26;16(7):e65454. doi: 10.7759/cureus.65454. eCollection 2024 Jul.

DOI:10.7759/cureus.65454
PMID:39184693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11345086/
Abstract

This case report describes a 65-year-old male who presented to the emergency department with significant lactic acidosis after self-poisoning by ingesting bispyribac sodium, a commonly known herbicide. This case highlights the rarity of poisoning with freely available herbicides in the literature, which may be elusive in clinical history and life-threatening in presentation. The patient had attempted to commit suicide with ingestion of an unidentified herbicide and was brought to the emergency department post two hours after the incident. He complained of abdominal pain. The hemodynamics of the patient were within normal limits. However, his initial lactate levels were elevated along with a high anion gap metabolic acidosis. The patient was provided symptomatic care and close monitoring. The ingested substance was later found to be bispyribac sodium. The patient symptomatically improved over time, with lactate levels attaining normal ranges, and was discharged after observation of 24 hours. Human ingestion of bispyribac sodium is mostly asymptomatic and non-fatal. The management in this case mainly consisted of symptomatic care. The initial presentation of herbicide poisoning in an emergency department setting as lactic acidosis and the subsequent evaluation to rule out other possible causes of lactic acidosis in the patient was challenging for the treating physician. The possibility of herbicide-mediated cellular damage and subsequent lactic acidosis is thought to be the reason for this rare presentation.

摘要

本病例报告描述了一名65岁男性,因误服常见除草剂双草醚而出现严重乳酸酸中毒后被送往急诊科。该病例凸显了文献中关于可随意获取的除草剂中毒情况的罕见性,这种中毒在临床病史中可能难以察觉,而在临床表现上则可能危及生命。患者曾试图服用一种不明除草剂自杀,事件发生两小时后被送往急诊科。他主诉腹痛。患者的血流动力学在正常范围内。然而,其初始乳酸水平升高,同时伴有高阴离子间隙代谢性酸中毒。患者接受了对症治疗和密切监测。后来发现摄入的物质是双草醚。随着时间的推移,患者症状有所改善,乳酸水平恢复正常范围,经过24小时观察后出院。人类摄入双草醚大多无症状且无致命危险。该病例的治疗主要包括对症治疗。在急诊科环境中,除草剂中毒最初表现为乳酸酸中毒,以及随后对患者排除乳酸酸中毒其他可能原因的评估,对主治医生来说具有挑战性。除草剂介导的细胞损伤及随后的乳酸酸中毒被认为是这种罕见表现的原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/129b/11345086/1100d9020a93/cureus-0016-00000065454-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/129b/11345086/2f9ebe58a191/cureus-0016-00000065454-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/129b/11345086/41d7f4323a27/cureus-0016-00000065454-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/129b/11345086/1100d9020a93/cureus-0016-00000065454-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/129b/11345086/2f9ebe58a191/cureus-0016-00000065454-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/129b/11345086/41d7f4323a27/cureus-0016-00000065454-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/129b/11345086/1100d9020a93/cureus-0016-00000065454-i03.jpg

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本文引用的文献

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Lancet Reg Health Southeast Asia. 2023 Aug 17;16:100265. doi: 10.1016/j.lansea.2023.100265. eCollection 2023 Sep.
2
Despite historic bans, south Asia still struggles with pesticide suicides.尽管有历史上的禁令,南亚仍在努力应对农药自杀问题。
BMJ. 2023 Apr 11;381:678. doi: 10.1136/bmj.p678.
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Lactic Acidosis Related to Pharmacotherapy and Human Diseases.与药物治疗及人类疾病相关的乳酸性酸中毒
Pharmaceuticals (Basel). 2022 Nov 30;15(12):1496. doi: 10.3390/ph15121496.
4
Metolachlor Poisoning with Lactic Acidosis Improved by Thiamine Administration: A Case Report.甲草胺中毒合并乳酸性酸中毒经硫胺素治疗后改善:病例报告。
Am J Case Rep. 2022 Oct 18;23:e937873. doi: 10.12659/AJCR.937873.
5
Lactate Level Versus Lactate Clearance for Predicting Mortality in Patients With Septic Shock Defined by Sepsis-3.乳酸水平与乳酸清除率对 Sepsis-3 定义的脓毒性休克患者病死率的预测价值
Crit Care Med. 2018 Jun;46(6):e489-e495. doi: 10.1097/CCM.0000000000003030.
6
Glyphosate surfactant herbicide poisoning and management.草甘膦表面活性剂除草剂中毒与处理
Indian J Crit Care Med. 2014 May;18(5):328-30. doi: 10.4103/0972-5229.132508.
7
Acute human self-poisoning with bispyribac-containing herbicide Nominee: a prospective observational study.急性人类口服含双吡氟草醚的除草剂 Nominee 中毒:一项前瞻性观察研究。
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8
The hazards of gastric lavage for intentional self-poisoning in a resource poor location.在资源匮乏地区对故意自我中毒进行洗胃的危害。
Clin Toxicol (Phila). 2007;45(2):136-43. doi: 10.1080/15563650601006009.