Eddleston Michael, Haggalla Sapumal, Reginald K, Sudarshan K, Senthilkumaran M, Karalliedde Lakshman, Ariaratnam Ariaranee, Sheriff M H Rezvi, Warrell David A, Buckley Nick A
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, England.
Clin Toxicol (Phila). 2007;45(2):136-43. doi: 10.1080/15563650601006009.
The 10-20% case fatality found with self-poisoning in the developing world differs markedly from the 0.5% found in the West. This may explain in part why the recent movement away from the use of gastric lavage in the West has not been followed in the developing world. After noting probable harm from gastric lavage in Sri Lanka, we performed an observational study to determine how lavage is routinely performed and the frequency of complications.
Fourteen consecutive gastric lavages were observed in four hospitals. Lavage was given to patients unable or unwilling to undergo forced emesis, regardless of whether they gave consent or the time elapsed since ingestion. It was also given to patients who had taken non-lethal ingestions. The airway was rarely protected in patients with reduced consciousness, large volumes of fluid were given for each cycle (200 to more than 1000 ml), and monitoring was not used. Serious complications likely to be due to the lavage were observed, including cardiac arrest and probable aspiration of fluid. Health care workers perceived lavage as being highly effective and often life-saving; there was peer and relative pressure to perform lavage in self-poisoned patients.
Gastric lavage as performed for highly toxic poisons in a resource-poor location is hazardous. In the absence of evidence for patient benefit from lavage, (and in agreement with some local guidelines), we believe that lavage should be considered for few patients - in those who have recently taken a potentially fatal dose of a poison, and who either give their verbal consent for the procedure or are sedated and intubated. Ideally, a randomized controlled trial should be performed to determine the balance of risks and benefits of safely performed gastric lavage in this patient population.
在发展中国家,自服毒物导致的病死率为10% - 20%,这与西方国家0.5%的病死率显著不同。这可能部分解释了为何西方国家近期摒弃洗胃疗法的做法未在发展中国家得到效仿。在注意到洗胃在斯里兰卡可能造成危害后,我们开展了一项观察性研究,以确定洗胃的常规操作方式及并发症的发生率。
在四家医院观察了连续14例洗胃病例。无论患者是否同意或服毒后经过了多长时间,均对无法或不愿接受催吐的患者进行洗胃。对摄入非致命性毒物的患者也进行洗胃。意识减弱的患者很少得到气道保护,每个洗胃周期注入大量液体(200至1000多毫升),且未进行监测。观察到了可能由洗胃导致的严重并发症,包括心脏骤停和可能的液体误吸。医护人员认为洗胃非常有效且常常能挽救生命;对于自服毒物的患者,存在同行和亲属要求进行洗胃的压力。
在资源匮乏地区对剧毒毒物进行洗胃是危险的。在缺乏证据表明洗胃对患者有益的情况下(并且与一些当地指南一致),我们认为仅对少数患者考虑洗胃——即那些近期摄入了可能致命剂量毒物、口头同意接受该操作或已接受镇静和插管的患者。理想情况下,应进行一项随机对照试验,以确定在这类患者中安全进行洗胃的风险和益处的平衡。