Mahendrakar Kranthi, Venkategowda Pradeep M, Rao S Manimala, Mutkule Dnyaneshwar P
Department of Critical Care Medicine, Yashoda Multi Speciality Hospital, Somajiguda, Hyderabad, Andhra Pradesh, India.
Indian J Crit Care Med. 2014 May;18(5):328-30. doi: 10.4103/0972-5229.132508.
Glyphosate is a widely used herbicide in agriculture, forestry, industrial weed control and aquatic environments. Glyphosate potential as herbicide was first reported in 1971. It is a non-selective herbicide. It can cause a wide range of clinical manifestations in human beings like skin and throat irritation to hypotension, oliguria and death. We are reporting a case of a 35-year-old male patient who was admitted to our tertiary care hospital following intentional ingestion of around 200 ml of herbicide containing glyphosate. Initially, gastric lavage done and the patient was managed with intubation and mechanical ventilation, noradrenaline and vasopressin infusion, continuous veno-venous hemodiafiltration and intravenous (IV) lipid emulsion (20% intralipid 100 ml), patient was successfully treated and discharged home. This case report emphasizes on timely systemic supportive measure as a sole method of treatment since this poison has no known specific antidote and the use of IV lipid emulsion for a successful outcome.
草甘膦是一种广泛应用于农业、林业、工业杂草防治及水生环境的除草剂。草甘膦作为除草剂的潜力于1971年首次被报道。它是一种非选择性除草剂。它可在人类身上引发广泛的临床表现，从皮肤和喉咙刺激到低血压、少尿乃至死亡。我们报告一例35岁男性患者，其在故意摄入约200毫升含草甘膦的除草剂后被收治于我们的三级护理医院。最初进行了洗胃，并对患者进行插管及机械通气、去甲肾上腺素和血管加压素输注、持续静脉 - 静脉血液透析滤过以及静脉注射（IV）脂质乳剂（20%英脱利匹特100毫升）治疗，患者最终成功治愈并出院。本病例报告强调了由于这种毒物尚无已知特效解毒剂，及时的全身支持措施作为唯一治疗方法的重要性，以及静脉注射脂质乳剂对于取得成功治疗效果的作用。
