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探索肝硬化中的血液学并发症:一项综合综述。

Exploring Haematological Complications in Cirrhosis of the Liver: A Comprehensive Review.

作者信息

Tantia Parav, Aggarwal Parth, Acharya Sourya, Kumar Sunil, Kothari Manjeet, Kadam Abhinav, Patil Rajvardhan

机构信息

Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

出版信息

Cureus. 2024 Jul 24;16(7):e65319. doi: 10.7759/cureus.65319. eCollection 2024 Jul.

Abstract

Various chronic liver diseases inevitably end up with cirrhosis of the liver, and this comes with a whole range of haematological complications. Therefore, this detailed review has discussed pathophysiology, clinical manifestations, diagnostic measures, and treatment plans for these anomalies. Closely related are conditions such as anaemia, thrombocytopenia, coagulopathy, leukopenia, and haemolytic disorders, which are known to contribute to morbidity and mortality in cirrhotic patients significantly. Therefore, we need to understand the causes of these problems to find ways of helping our patients better. For this reason, multidisciplinary management will be key in ensuring proper monitoring, timely intervention, and preventive measures for haematological abnormalities in cirrhosis. Additionally, there have been tremendous advancements in therapeutic options, like adjunctive therapies or haematopoietic growth factors, which hold much promise regarding patient outcomes. This article emphasizes the proactive management of haematological complications associated with cirrhosis while highlighting the need for further research coupled with collaboration aimed at strengthening prevention strategies, diagnostic methods, and curative interventions.

摘要

各种慢性肝病最终不可避免地会发展为肝硬化,随之而来的是一系列血液学并发症。因此,本详细综述讨论了这些异常情况的病理生理学、临床表现、诊断措施和治疗方案。与之密切相关的病症包括贫血、血小板减少、凝血病、白细胞减少和溶血性疾病,这些病症已知会显著增加肝硬化患者的发病率和死亡率。因此,我们需要了解这些问题的成因,以便找到更好地帮助患者的方法。出于这个原因,多学科管理对于确保对肝硬化患者血液学异常进行适当监测、及时干预和采取预防措施至关重要。此外,在治疗选择方面已经取得了巨大进展,如辅助治疗或造血生长因子,这些对患者的治疗结果很有前景。本文强调对肝硬化相关血液学并发症的积极管理,同时强调需要进一步研究并加强合作,以强化预防策略、诊断方法和治疗干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4171/11344626/fc175252d073/cureus-0016-00000065319-i01.jpg

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