Balan Kerem, Aydın Furkan, Akdogan Neslihan
Dermatology, Hacettepe University, Ankara, TUR.
Cureus. 2024 Jul 26;16(7):e65402. doi: 10.7759/cureus.65402. eCollection 2024 Jul.
Acute localized exanthematous pustulosis (ALEP) is typically a benign drug reaction that occurs shortly after drug intake. We report a five-year-old male who developed a localized, zosteriform pustular rash on his back 10 days after treatment with oseltamivir and ceftriaxone for an upper respiratory tract infection. The lesions, which appeared three days prior to presentation, were mildly itchy and resolved completely without scarring within two days of treatment with topical betamethasone valerate and fusidic acid. No bacterial growth was detected in the pustular culture. This case highlights the rare occurrence of ALEP in a pediatric patient and suggests variations from the EuroSCAR diagnostic criteria, which usually indicate a 72-hour onset post-drug intake, noting instead a 7-14 day onset in atypical cases.To best of our knowledge, This is the first report of ALEP presenting with a zosteriform distribution.
急性局限性脓疱性发疹病（ALEP）通常是一种良性药物反应，在服药后不久发生。我们报告一名5岁男性，在用奥司他韦和头孢曲松治疗上呼吸道感染10天后，背部出现局限性带状疱疹样脓疱疹。皮损在就诊前3天出现，轻度瘙痒，外用戊酸倍他米松和夫西地酸治疗2天内完全消退，无瘢痕形成。脓疱培养未检测到细菌生长。该病例突出了ALEP在儿科患者中的罕见发生，并提示与欧洲药品不良反应监测网（EuroSCAR）诊断标准存在差异，该标准通常表明服药后72小时发病，而非典型病例则为7 - 14天发病。据我们所知，这是首例呈带状疱疹样分布的ALEP报告。
