The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Department of Orthopedics, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Tumori. 2024 Oct;110(5):327-339. doi: 10.1177/03008916241271458. Epub 2024 Aug 26.
Single-cell techniques have convincingly demonstrated that tumor tissue usually contains multiple genetically defined cell subclones with different gene mutation sets as well as various transcriptional profiles, but the spatial heterogeneity of the microenvironment and the macrobiological characteristics of the tumor ecosystem have not been described. For the past few years, spatial multi-omics technologies have revealed the cellular interactions, microenvironment, and even systemic tumor-host interactions in the tumor ecosystem at the spatial level, which can not only improve classical therapies such as surgery, radiotherapy, and chemotherapy but also promote the development of emerging targeted therapies in immunotherapy. Here, we review some emerging spatial omics techniques in cancer research and therapeutic applications and propose prospects for their future development.
单细胞技术令人信服地表明，肿瘤组织通常包含多个具有不同基因突变集和不同转录谱的遗传定义的细胞亚克隆，但肿瘤生态系统的微环境空间异质性和宏观生物学特征尚未得到描述。在过去的几年中，空间多组学技术在空间水平上揭示了肿瘤生态系统中的细胞相互作用、微环境，甚至全身肿瘤-宿主相互作用，不仅可以改善手术、放疗和化疗等经典疗法，还可以促进免疫治疗中新兴靶向疗法的发展。在这里，我们回顾了癌症研究和治疗应用中一些新兴的空间组学技术，并对它们的未来发展提出了展望。
