癌症治疗中的空间多组学革命：精准医学的新定义。
The spatial multi-omics revolution in cancer therapy: Precision redefined.
机构信息
Shanghai Institute of Immunology, State Key Laboratory of Oncogenes and Related Genes, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Shanghai Institute of Immunology, State Key Laboratory of Oncogenes and Related Genes, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
出版信息
Cell Rep Med. 2024 Sep 17;5(9):101740. doi: 10.1016/j.xcrm.2024.101740.
Abstract
Spatially resolved multi-omics revolutionizes cancer therapy by decoding the cellular and molecular heterogeneity of the tumor microenvironment through spatial coordinates. This commentary discusses the roles of spatial multi-omics in identifying precise therapeutic targets and predicting treatment responses while also highlighting the challenges that impede its integration into precision medicine.
摘要
空间解析多组学通过空间坐标解码肿瘤微环境的细胞和分子异质性，从而彻底改变癌症治疗。本文讨论了空间多组学在识别精确治疗靶点和预测治疗反应方面的作用，同时强调了阻碍其纳入精准医学的挑战。
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