Meade T W, Vickers M V, Thompson S G, Stirling Y, Haines A P, Miller G J
Br Med J (Clin Res Ed). 1985 Feb 9;290(6466):428-32. doi: 10.1136/bmj.290.6466.428.
The epidemiological characteristics of platelet aggregability were established in 958 participants in the Northwick Park Heart Study. The main analyses were based on the dose of adenosine diphosphate at which primary aggregation occurred at half its maximum velocity. Aggregability increased with age in both sexes, was greater in whites than blacks (particularly among men), and tended to decrease with the level of habitual alcohol consumption. Aggregability was, however, greater in women than men and in nonsmokers than smokers. There was no relation between aggregability on the one hand and obesity, current or past oral contraceptive use, menopausal state, or blood cholesterol and triglyceride concentrations on the other. Aggregability was somewhat, though not significantly, higher in men with a history of ischaemic heart disease and in those with electrocardiographic evidence of ischaemia than in those without. There was a strong association between the plasma fibrinogen concentration and aggregability. The widely held concept of platelet aggregability and its implications is probably an oversimplification. In the prevention of thrombosis it may be as useful to consider modifying external influences on platelet behaviour, such as plasma fibrinogen concentration or thrombin production, as it is to rely solely on platelet active agents.
在诺斯威克公园心脏研究的958名参与者中确定了血小板聚集性的流行病学特征。主要分析基于二磷酸腺苷的剂量，此时初级聚集以其最大速度的一半发生。两性的聚集性均随年龄增长而增加，白人高于黑人（尤其是男性），并且倾向于随着习惯性饮酒量的增加而降低。然而，女性的聚集性高于男性，不吸烟者高于吸烟者。一方面，聚集性与肥胖、当前或过去使用口服避孕药、绝经状态或血液胆固醇和甘油三酯浓度之间没有关联。有缺血性心脏病病史的男性以及有心电图缺血证据的男性的聚集性虽不显著但略高于无上述情况的男性。血浆纤维蛋白原浓度与聚集性之间存在密切关联。关于血小板聚集性及其影响的广泛概念可能过于简单化。在预防血栓形成方面，考虑改变对血小板行为的外部影响，如血浆纤维蛋白原浓度或凝血酶生成，可能与仅依赖血小板活性剂一样有用。
