乳腺癌中超快速动态对比增强（DCE）MRI的动力学参数与肿瘤浸润淋巴细胞（TILs）之间的关系。
Relationship between kinetic parameters of ultrafast dynamic contrast-enhanced (DCE) MRI and tumor-infiltrating lymphocytes (TILs) in breast cancer.
作者信息
Yamaguchi Ken, Nakazono Takahiko, Egashira Ryoko, Fukui Shuichi, Imaizumi Tsutomu, Maruyama Katsuya, Nickel Dominik, Hamamoto Takahiro, Yamaguchi Rin, Irie Hiroyuki
机构信息
Department of Radiology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, 849-8501, Japan.
MR Research & Collaboration Department, Siemens Healthcare K.K., Gate City Osaki West Tower, 1-11-1 Osaki, Shinagawa-Ku, Tokyo, 141-8644, Japan.
出版信息
Jpn J Radiol. 2025 Jan;43(1):43-50. doi: 10.1007/s11604-024-01645-w. Epub 2024 Aug 26.
PURPOSE
To evaluate the relationship between kinetic parameters of ultrafast dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and tumor-infiltrating lymphocytes (TILs) in breast cancer.
PATIENTS AND METHODS
This retrospective study was approved by an institutional review board and included 76 women (median age: 60) with 76 surgically proven breast cancers who underwent DCE MRI including ultrafast sequence. Based on the TILs level, we classified the patients into the low-TILs (< 10%) group and the high-TILs (≥ 10%) group. Maximum slope (MS) and time to enhancement (TTE) derived from ultrafast DCE sequence were correlated in each TILs group. The percentages of six kinetic patterns (fast, medium, and slow from the early phase, washout, plateau, and persistent from the delayed phase) derived from the conventional DCE sequence were also correlated in each TILs group.
RESULTS
Of the 76 breast cancers, 57 were in the low-TILs group and 19 comprised the high-TILs group. The median MS in the high-TILs group (32.4%/sec) was significantly higher than that in the low-TILs group (23.68%/s) (p = 0.037). In a receiver-operating characteristic (ROC) analysis, the area under the curve (AUC) for differentiating between the high- and low-TILs group was 0.661. The TTE in the high-TILs group was significantly shorter than that in the low-TILs group (p = 0.012). In the ROC analysis, the AUC was 0.685. There were no significant differences between the percentages of the six kinetic patterns from the conventional DCE sequence and the TILs level (p = 0.075-0.876).
CONCLUSION
Compared to the low-TILs group, the high-TILs group had higher MS and shorter TTE.
目的
评估超快动态对比增强（DCE）磁共振成像（MRI）的动力学参数与乳腺癌肿瘤浸润淋巴细胞（TILs）之间的关系。
患者与方法
本回顾性研究经机构审查委员会批准，纳入了76例经手术证实患有乳腺癌的女性（中位年龄：60岁），这些患者均接受了包括超快序列在内的DCE MRI检查。根据TILs水平，我们将患者分为低TILs（<10%）组和高TILs（≥10%）组。在每个TILs组中，分析超快DCE序列得出的最大斜率（MS）和强化时间（TTE）之间的相关性。同时，在每个TILs组中，分析传统DCE序列得出的六种动力学模式（早期的快速、中等和慢速，延迟期的廓清、平台期和持续期）的百分比之间的相关性。
结果
76例乳腺癌中，57例属于低TILs组，19例属于高TILs组。高TILs组的中位MS（32.4%/秒）显著高于低TILs组（23.68%/秒）（p = 0.037）。在受试者操作特征（ROC）分析中，区分高TILs组和低TILs组的曲线下面积（AUC）为0.661。高TILs组的TTE显著短于低TILs组（p = 0.012）。在ROC分析中，AUC为0.685。传统DCE序列的六种动力学模式的百分比与TILs水平之间无显著差异（p = 0.075 - 0.876）。
结论
与低TILs组相比，高TILs组具有更高的MS和更短的TTE。
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