Molecular Biotechnology Laboratory, School of Biotechnology, Institute of Agricultural Technology, Suranaree University of Technology, Suranaree, Muang, 111 University Avenue, Nakhon Ratchasima 30000, Thailand.
Institute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of Sciences, Lavrentieva 8/2, Novosibirsk 630090, Russia.
N Biotechnol. 2024 Nov 25;83:205-218. doi: 10.1016/j.nbt.2024.08.506. Epub 2024 Aug 24.
Antibodies and antibody-based immunotherapeutics are the mainstays of cancer immunotherapy. Expanding the repertoire of cancer-specific and cancer-associated epitopes targetable with antibodies represents an important area of research. Phage display is a powerful approach allowing the use of diverse antibody libraries to be screened for binding to a wide range of targets. In this review, we summarize the basics of phage display technology and highlight the advances in anticancer antibody identification and modification via phage display platform. Finally, we describe phage display-derived anticancer monoclonal antibodies that have been approved to date or are in clinical development.
抗体和基于抗体的免疫疗法是癌症免疫疗法的主要手段。扩大可与抗体结合的癌症特异性和癌症相关表位的 repertoire 是一个重要的研究领域。噬菌体展示是一种强大的方法，允许使用各种抗体文库筛选与广泛的靶标结合。在这篇综述中，我们总结了噬菌体展示技术的基础知识，并强调了通过噬菌体展示平台鉴定和修饰抗癌抗体的进展。最后，我们描述了迄今为止已获得批准或正在临床开发的基于噬菌体展示的抗癌单克隆抗体。
