Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec, H3T 1A8, Canada.
Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada.
Clin Nutr ESPEN. 2024 Oct;63:952-958. doi: 10.1016/j.clnesp.2024.08.016. Epub 2024 Aug 24.
BACKGROUND & AIMS: Cystic fibrosis (CF)-related diabetes (CFRD), a common comorbidity in CF, is often preceded and characterized with elevated postprandial glycemic (PPG) excursions. In the general population, the consumption of a pre-meal protein snack and/or physical activity (PA) hinder the elevation of PPG levels. Our objective is to evaluate the effect of a pre-meal snack and/or post-meal PA on PPG excursions in CF.
This is a double-blinded randomized controlled crossover interventional study in 14 adults with CF, with 4 interventions: placebo pre-meal snack + no PA (control: CTL), pre-meal soy snack + no PA (SK), placebo pre-meal snack + PA (PA), and pre-meal soy snack + PA (SK + PA). The pre-meal soy snack or placebo beverage (vanilla flavoured water) is served at 8 AM, followed by a standardized breakfast at 9 AM and, postprandially, 5 repeated bouts of 3-min walk every 30 min or sedentary activity. Blood glucose and insulin were measured every 15-30 min during the interventions.
Plasma glucose (PG) was higher 30 min after snack consumption compared to placebo beverage. One-hour post-breakfast, PG levels were lower during both PA interventions than with sedentary behavior. However, the overall 3 h post-breakfast glucose area under the curve (AUC) was similar between interventions. Post-breakfast 3 h insulin AUC was significantly lower during the SK + PA intervention compared to the sedentary behavior interventions.
Repeated short bouts of post-meal physical activity may positively impact PPG control in adults with CF, with or without the addition of a pre-meal soy snack. A pre-meal snack alone does not improve PPG.
囊性纤维化（CF）相关糖尿病（CFRD）是 CF 的常见合并症，通常伴有餐后血糖（PPG）升高。在普通人群中，餐前摄入蛋白质零食和/或进行身体活动（PA）可抑制 PPG 水平升高。本研究旨在评估餐前零食和/或餐后 PA 对 CF 患者 PPG 波动的影响。
这是一项在 14 名 CF 成人中进行的双盲随机对照交叉干预研究，共包括 4 种干预措施：安慰剂餐前零食+无 PA（对照：CTL）、餐前大豆零食+无 PA（SK）、安慰剂餐前零食+PA（PA）和餐前大豆零食+PA（SK+PA）。8 点时给予餐前大豆零食或安慰剂饮料（香草味水），随后在 9 点进标准早餐，进餐后每 30 分钟进行 5 次 3 分钟步行或静坐活动，每 15-30 分钟测量一次血糖和胰岛素。
与安慰剂饮料相比，零食摄入后 30 分钟时血浆葡萄糖（PG）升高。早餐后 1 小时，与静坐行为相比，两种 PA 干预措施的 PG 水平均较低。然而，早餐后 3 小时的整体血糖曲线下面积（AUC）在各干预组之间相似。与静坐行为干预相比，SK+PA 干预后早餐后 3 小时胰岛素 AUC 显著降低。
餐后多次短暂的身体活动可能对 CF 成人的 PPG 控制产生积极影响，无论是否添加餐前大豆零食。单独的餐前零食并不能改善 PPG。
