Research center of Centre Hospitalier Universitaire Sainte-Justine, Montréal, Canada.
Research center of Centre Hospitalier Universitaire Sainte-Justine, Montréal, Canada; Department of Preventive and Social Medicine, School of Public Health, Université de Montréal, Montréal, Canada; Research center of Centre Hospitalier de l'Université de Montréal, Montréal, Canada.
J Affect Disord. 2024 Dec 15;367:486-495. doi: 10.1016/j.jad.2024.08.138. Epub 2024 Aug 24.
Youth obesity and depression are public health concerns. Although meta-analyses suggest a positive association between those conditions in adults and adolescents, evidence remains unclear in prepubertal children. We examined the bidirectional associations between levels of depressive symptoms and weight status in 8-10-year-old children with a parental history of obesity, over two years, and whether they differ by sex.
Data were drawn from the QUebec Adipose and Lifestyle InvesTigation in Youth Cohort Study's baseline and first follow-up evaluations (n = 558). Depressive symptoms were assessed using the 12-item Center for Epidemiological Studies Depression scale and weight status using body mass index z-scores based on World Health Organization standards. Linear and logistic regression models were used to test the directionality and magnitude of the associations, adjusting for age, sex, physical activity, screen time, parental education, alcohol and cigarette use, and baseline outcome measure.
Children with higher levels of depressive symptoms at baseline were not more likely to have overweight/obesity at follow-up (odds ratio [95 % Coefficient Interval] = 0.95[0.88;1.02]). Baseline overweight/obesity was not associated with subsequent higher levels of depressive symptoms (beta coefficient [95 % Coefficient Interval] = 0.20 [-0.47;0.87]). No sex differences emerged.
Selection bias may have occurred due to loss at follow-up (10 % attrition) and exclusion of 6 participants taking mood disorder medication.
Unlike in adults and adolescents, no association between weight status and depressive symptoms was observed in childhood over two years. Underlying mechanisms linking both conditions later in life may not apply as early as prepubertal childhood.
青少年肥胖和抑郁是公共卫生关注的问题。虽然荟萃分析表明成年人和青少年的这些情况之间存在正相关，但在青春期前儿童中，证据仍然不清楚。我们在两年内检查了有肥胖家族史的 8-10 岁儿童中抑郁症状水平与体重状况之间的双向关联，以及它们是否因性别而异。
数据来自魁北克青少年脂肪和生活方式调查队列研究的基线和第一次随访评估（n=558）。使用 12 项中心流行病学研究抑郁量表评估抑郁症状，使用世界卫生组织标准的体重指数 z 分数评估体重状况。使用线性和逻辑回归模型测试关联的方向性和大小，调整年龄、性别、体育活动、屏幕时间、父母教育、酒精和香烟使用以及基线结果测量。
基线时抑郁症状水平较高的儿童在随访时不太可能超重/肥胖（比值比[95%置信区间]为 0.95[0.88;1.02]）。基线超重/肥胖与随后出现更高水平的抑郁症状无关（β系数[95%置信区间]为 0.20[-0.47;0.87]）。没有出现性别差异。
由于随访时的失访（10%的流失率）和排除 6 名服用情绪障碍药物的参与者，可能存在选择偏倚。
与成年人和青少年不同，在两年内，儿童的体重状况和抑郁症状之间没有关联。在青春期前儿童时期，可能不适用以后生活中联系两种情况的潜在机制。
