Stingeni Luca, Napolitano Maddalena, Hansel Katharina, Foti Caterina, Corazza Monica, Borghi Alessandro, Gallo Rosella, Patruno Cataldo, Schena Donatella, Lauriola Maria Michela, Casciola Gabriele, Giuffrida Roberta, Guarneri Fabrizio
Section of Dermatology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Contact Dermatitis. 2025 Jan;92(1):9-20. doi: 10.1111/cod.14684. Epub 2024 Aug 26.
Hand eczema (HE) is a common skin disease with a negative impact on patients' quality of life in occupational and non-occupational settings. Up-to-date, data on HE in Italian patients referred for patch testing are lacking.
To characterise the profile in terms of demographics, aetiology and patch test results of Italian patients affected by HE referred for patch testing.
A retrospective descriptive study on consecutive patients affected by HE who underwent patch testing from 2016 to 2023 in eight dermatology clinics was performed. HE patients were divided into two groups according to the exclusive (HE-only group) and not-exclusive (HE+ group) hand involvement, and compared to patients with eczema localised in body areas other than hands (NHE group).
One thousand five hundred and ninety-seven patients were affected by HE (35.3% males; mean age 42.7 years), 60.2% belonging to the HE-only group and 39.8% to the HE+ group. Occupational dermatitis was diagnosed in 33.2% of HE-only patients, 25.0% of HE+ patients and 5.2% of NHE patients (p < 0.001). HE-only patients presented: Allergic Contact Dermatitis (ACD), Irritant Contact Dermatitis (ICD), atopic HE in 48.1%, 47.5% and 7.1%, respectively; hyperkeratotic palmar, acute recurrent vesicular and nummular clinical subtypes in 52.2%, 43.9% and 11.9%, respectively; relevant positive patch test reactions in 48.1% (nickel sulphate 18.9%, methylchloroisothiazolinone/methylisothiazolinone 10.6%, methylisothiazolinone 8.6%, p-phenylenediamine 6.0% and potassium dichromate 4.7%).
HE patients, and particularly those with exclusive hand involvement, show a particular profile in terms of demographic and clinical characteristics, etiologies and relevant positive patch test reactions.
手部湿疹（HE）是一种常见的皮肤病，对患者在职业和非职业环境中的生活质量有负面影响。目前，缺乏意大利接受斑贴试验的患者中手部湿疹的数据。
描述因手部湿疹接受斑贴试验的意大利患者在人口统计学、病因和斑贴试验结果方面的特征。
对2016年至2023年在八家皮肤科诊所接受斑贴试验的连续性手部湿疹患者进行回顾性描述性研究。手部湿疹患者根据手部是否为唯一受累部位分为两组（仅手部湿疹组）和非唯一受累部位组（手部湿疹+组），并与湿疹局限于手部以外身体部位的患者（非手部湿疹组）进行比较。
1597例患者患有手部湿疹（男性占35.3%；平均年龄42.7岁），60.2%属于仅手部湿疹组，39.8%属于手部湿疹+组。仅手部湿疹组患者中33.2%被诊断为职业性皮炎，手部湿疹+组患者中为25.0%，非手部湿疹组患者中为5.2%（p<0.001）。仅手部湿疹组患者中：过敏性接触性皮炎（ACD）、刺激性接触性皮炎（ICD）、特应性手部湿疹分别占48.1%、47.5%和7.1%；角化过度性掌部、急性复发性水疱性和钱币状临床亚型分别占52.2%、43.9%和11.9%；斑贴试验相关阳性反应占48.1%（硫酸镍18.9%、甲基氯异噻唑啉酮/甲基异噻唑啉酮10.6%、甲基异噻唑啉酮8.6%、对苯二胺6.0%、重铬酸钾4.7%）。
手部湿疹患者，尤其是仅手部受累的患者，在人口统计学和临床特征、病因及斑贴试验相关阳性反应方面表现出特定特征。
