Department of Spine Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Endoscopy, Sun Yat-sen University Cancer Center, Guangzhou, China.
J Cell Mol Med. 2024 Aug;28(16):e70012. doi: 10.1111/jcmm.70012.
Neuritin, also known as candidate plasticity gene 15 (CPG15), was first identified as one of the activity-dependent gene products in the brain. Previous studies have been reported that Neuritin induces neuritogenesis, neurite arborization, neurite outgrowth and synapse formation, which are involved in the development and functions of the central nervous system. However, the role of Neuritin in peripheral nerve injury is still unknown. Given the importance and necessity of Schwann cell dedifferentiation response to peripheral nerve injury, we aim to investigate the molecular mechanism of Neuritin steering Schwann cell dedifferentiation during Wallerian degeneration (WD) in injured peripheral nerve. Herein, using the explants of sciatic nerve, an ex vivo model of nerve degeneration, we provided evidences indicating that Neuritin vividly accelerates Schwann cell dedifferentiation. Moreover, we found that Neuritin promotes Schwann cell demyelination as well as axonal degeneration, phagocytosis, secretion capacity. In summary, we first described Neuritin acts as a positive regulator for Schwann cell dedifferentiation and WD after peripheral nerve injury.
神经黏附素，又称候选可塑性基因 15（CPG15），最初被鉴定为大脑中活性依赖性基因产物之一。先前的研究已经表明，神经黏附素诱导神经突生成、树突分支、神经突生长和突触形成，这些过程涉及中枢神经系统的发育和功能。然而，神经黏附素在外周神经损伤中的作用尚不清楚。鉴于雪旺细胞去分化反应对周围神经损伤的重要性和必要性，我们旨在研究神经黏附素在损伤的周围神经中沃勒变性（WD）过程中指导雪旺细胞去分化的分子机制。在此，我们使用坐骨神经外植体，一种神经退行性变的体外模型，提供了证据表明神经黏附素能明显加速雪旺细胞去分化。此外，我们发现神经黏附素促进雪旺细胞脱髓鞘以及轴突变性、吞噬作用和分泌能力。总之，我们首次描述了神经黏附素在外周神经损伤后作为雪旺细胞去分化和 WD 的正调控因子发挥作用。
