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Effect of oral faecal microbiota transplantation intervention for children with autism spectrum disorder: A randomised, double-blind, placebo-controlled trial.

作者信息

Wan Lin, Wang Huan, Liang Yan, Zhang Xun, Yao Xinyun, Zhu Gang, Cai Jun, Liu Guoyin, Liu Xinting, Niu Qianqian, Li Siwen, Zhang Bo, Gao Jing, Wang Jing, Shi Xiuyu, Hu Linyan, Liu Xiaoyan, Zou Zhiyong, Yang Guang

机构信息

Senior Department of Pediatrics, The Seventh Medical Centre of PLA General Hospital, Beijing, China.

Department of Pediatrics, The First Medical Centre, Chinese PLA General Hospital, Beijing, China.

出版信息

Clin Transl Med. 2024 Sep;14(9):e70006. doi: 10.1002/ctm2.70006.

DOI:10.1002/ctm2.70006
PMID:39187939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11347384/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb70/11347384/0546a41f3689/CTM2-14-e70006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb70/11347384/0546a41f3689/CTM2-14-e70006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb70/11347384/0546a41f3689/CTM2-14-e70006-g001.jpg

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Effect of oral faecal microbiota transplantation intervention for children with autism spectrum disorder: A randomised, double-blind, placebo-controlled trial.口服粪便微生物群移植干预对自闭症谱系障碍儿童的影响：一项随机、双盲、安慰剂对照试验。
Clin Transl Med. 2024 Sep;14(9):e70006. doi: 10.1002/ctm2.70006.
2
FTACMT study protocol: a multicentre, double-blind, randomised, placebo-controlled trial of faecal microbiota transplantation for autism spectrum disorder.FTACMT 研究方案：多中心、双盲、随机、安慰剂对照的粪便微生物群移植治疗自闭症谱系障碍的研究。
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Protocol for the Gut Bugs in Autism Trial: a double-blind randomised placebo-controlled trial of faecal microbiome transfer for the treatment of gastrointestinal symptoms in autistic adolescents and adults.自闭症肠道菌群试验方案：自闭症青少年和成年人肠道微生物群移植治疗胃肠道症状的双盲随机安慰剂对照试验。
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Nutrients. 2025 Jul 7;17(13):2250. doi: 10.3390/nu17132250.
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The Effects of Fecal Microbial Transplantation on the Symptoms in Autism Spectrum Disorder, Gut Microbiota and Metabolites: A Scoping Review.粪便微生物移植对自闭症谱系障碍症状、肠道微生物群和代谢产物的影响：一项范围综述
Microorganisms. 2025 May 31;13(6):1290. doi: 10.3390/microorganisms13061290.
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The Gut Microbiota in Young Adults with High-Functioning Autism Spectrum Disorder and Its Performance as Diagnostic Biomarkers.

本文引用的文献

1
Effects of Washed Fecal Bacteria Transplantation in Sleep Quality, Stool Features and Autism Symptomatology: A Chinese Preliminary Observational Study.洗过的粪便细菌移植对睡眠质量、粪便特征和自闭症症状的影响：一项中国初步观察性研究。
Neuropsychiatr Dis Treat. 2022 Jun 11;18:1165-1173. doi: 10.2147/NDT.S355233. eCollection 2022.
2
Deviated and early unsustainable stunted development of gut microbiota in children with autism spectrum disorder.自闭症谱系障碍儿童肠道微生物群早期偏离和不可持续的发育迟缓。
Gut. 2022 Aug;71(8):1588-1599. doi: 10.1136/gutjnl-2021-325115. Epub 2021 Dec 20.
3
Autism-related dietary preferences mediate autism-gut microbiome associations.
高功能自闭症谱系障碍青年的肠道微生物群及其作为诊断生物标志物的表现。
Nutrients. 2025 May 22;17(11):1748. doi: 10.3390/nu17111748.
4
Autism Spectrum Disorder, Oral Implications, and Oral Microbiota.自闭症谱系障碍、口腔影响与口腔微生物群
Children (Basel). 2025 Mar 15;12(3):368. doi: 10.3390/children12030368.
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decoction ameliorates abnormal behavior by regulating gut microbiota in rats with propionic acid-induced autism.汤剂通过调节丙酸诱导的自闭症大鼠的肠道微生物群来改善异常行为。
Front Microbiol. 2025 Feb 13;16:1535451. doi: 10.3389/fmicb.2025.1535451. eCollection 2025.
自闭症相关的饮食偏好可调节自闭症-肠道微生物组的关联。
Cell. 2021 Nov 24;184(24):5916-5931.e17. doi: 10.1016/j.cell.2021.10.015. Epub 2021 Nov 11.
4
Fecal Microbiota Transplantation Relieves Gastrointestinal and Autism Symptoms by Improving the Gut Microbiota in an Open-Label Study.在一项开放性研究中，通过改善肠道微生物群，粪便微生物移植可缓解胃肠道和自闭症症状。
Front Cell Infect Microbiol. 2021 Oct 19;11:759435. doi: 10.3389/fcimb.2021.759435. eCollection 2021.
5
Altered gut microbial profile is associated with abnormal metabolism activity of Autism Spectrum Disorder.肠道微生物谱的改变与自闭症谱系障碍的代谢活性异常有关。
Gut Microbes. 2020 Sep 2;11(5):1246-1267. doi: 10.1080/19490976.2020.1747329. Epub 2020 Apr 21.
6
Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study.微生物群转移治疗改变肠道生态系统，改善胃肠道和自闭症症状：一项开放标签研究。
Microbiome. 2017 Jan 23;5(1):10. doi: 10.1186/s40168-016-0225-7.