Becker S
Cell Immunol. 1985 Mar;91(1):301-7. doi: 10.1016/0008-8749(85)90053-x.
The effect of interferon-gamma (IFN-gamma) on antigen-induced and autologous proliferative responses has been investigated. The enhanced proliferative response, which resulted in the presence of IFN-gamma, was found to be the consequence of the increased density of HLA-DR induced on the accessory cells. The enhanced proliferation was at least partly due to a shift in the proliferation time course. The response to tetanus toxoid peaked 1-2 days earlier when IFN-gamma-treated monocytes acted as accessory cells than when untreated monocytes presented the antigen. Modulation of the level of DR by preincubation of the monocytes with anti-DR antibody with and without IFN-gamma demonstrated that both autologous and antigen-driven proliferation was influenced in proportion to the level of DR expressed at the time of stimulation. These experiments point to the importance of IFN-gamma in inducing an accelerated immune response via its effect on the density of DR expression on the accessory cell.
已经研究了γ干扰素（IFN-γ）对抗原诱导的和自身增殖反应的影响。发现IFN-γ存在时增强的增殖反应是辅助细胞上诱导的HLA-DR密度增加的结果。增殖增强至少部分归因于增殖时间进程的改变。当用IFN-γ处理的单核细胞作为辅助细胞时，对破伤风类毒素的反应比未处理的单核细胞呈递抗原时提前1-2天达到峰值。用抗DR抗体在有和没有IFN-γ的情况下对单核细胞进行预孵育来调节DR水平，结果表明自身增殖和抗原驱动的增殖均与刺激时表达的DR水平成比例地受到影响。这些实验表明IFN-γ通过其对辅助细胞上DR表达密度的影响在诱导加速的免疫反应中具有重要作用。
