Slepian I K, Mathews K P, McLean J A
Chest. 1985 Mar;87(3):386-91. doi: 10.1378/chest.87.3.386.
Aspirin intolerance is particularly common in asthmatic patients who additionally have chronic rhinitis and/or nasal polyps. These individuals differ in several respects from patients who experience urticaria and/or angioedema after aspirin administration, and differing mechanisms may be involved. Data regarding the latter are indirect and incomplete, but suggest that ASA-sensitive asthma is most likely to be related in some manner to the capacity of ASA to inhibit cyclooxygenases, enhanced lipoxygenase metabolism perhaps playing a crucial role. Current research employing ASA "desensitization" may help to elucidate these enigmas.
阿司匹林不耐受在患有慢性鼻炎和/或鼻息肉的哮喘患者中尤为常见。这些个体在几个方面与服用阿司匹林后出现荨麻疹和/或血管性水肿的患者不同，可能涉及不同的机制。关于后者的数据是间接且不完整的，但表明阿司匹林敏感性哮喘很可能在某种程度上与阿司匹林抑制环氧化酶的能力有关，增强的脂氧合酶代谢可能起关键作用。目前采用阿司匹林“脱敏”的研究可能有助于阐明这些谜团。
