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原发性皮肤黑色素瘤：黑色素瘤的一种罕见亚型及基底细胞癌的临床模仿者

Primary Dermal Melanoma: A Rare Subtype of Melanoma and Clinical Mimicker of Basal Cell Carcinoma.

作者信息

Owens Kelly E, Zegeye Ysaac, Saade Rayan, Pavlis Michelle B

机构信息

Department of Dermatology, Duke University School of Medicine, Durham, USA.

Department of Pathology, Duke University School of Medicine, Durham, USA.

出版信息

Cureus. 2024 Jul 27;16(7):e65538. doi: 10.7759/cureus.65538. eCollection 2024 Jul.

DOI:10.7759/cureus.65538
PMID:39188463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11346804/
Abstract

Primary dermal melanoma (PDM) is a rare variant of melanoma. We present the case of a 76-year-old female diagnosed with PDM following initial suspicion of basal cell carcinoma, prompting extensive workup to exclude metastasis. This case demonstrates the diagnostic challenges and need for rigorous evaluation in suspected PDM cases. Current literature lacks definitive diagnostic markers for PDM, and we highlight the ongoing need for research and collaborative efforts between dermatology and oncology.

摘要

原发性皮肤黑色素瘤（PDM）是黑色素瘤的一种罕见变体。我们报告了一例76岁女性病例，该患者最初被怀疑患有基底细胞癌，随后被诊断为PDM，这促使进行了广泛的检查以排除转移。该病例展示了疑似PDM病例的诊断挑战以及进行严格评估的必要性。目前的文献缺乏PDM的明确诊断标志物，我们强调皮肤病学和肿瘤学之间持续开展研究与合作的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ae/11346804/6405bb15c439/cureus-0016-00000065538-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ae/11346804/ee82610a538d/cureus-0016-00000065538-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ae/11346804/01a7540db02e/cureus-0016-00000065538-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ae/11346804/000c23e9fce3/cureus-0016-00000065538-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ae/11346804/6405bb15c439/cureus-0016-00000065538-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ae/11346804/ee82610a538d/cureus-0016-00000065538-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ae/11346804/01a7540db02e/cureus-0016-00000065538-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ae/11346804/000c23e9fce3/cureus-0016-00000065538-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ae/11346804/6405bb15c439/cureus-0016-00000065538-i04.jpg

相似文献

1
Primary Dermal Melanoma: A Rare Subtype of Melanoma and Clinical Mimicker of Basal Cell Carcinoma.原发性皮肤黑色素瘤：黑色素瘤的一种罕见亚型及基底细胞癌的临床模仿者
Cureus. 2024 Jul 27;16(7):e65538. doi: 10.7759/cureus.65538. eCollection 2024 Jul.
2
Lack of distinct molecular profile of Primary Dermal Melanoma.原发性皮肤黑素瘤缺乏独特的分子特征。
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Primary Dermal Melanoma: A Case Report.原发性皮肤黑素瘤：一例报告。
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Primary dermal melanoma: distinct immunohistochemical findings and clinical outcome compared with nodular and metastatic melanoma.原发性皮肤黑色素瘤：与结节性和转移性黑色素瘤相比，具有独特的免疫组化表现和临床结局。
Arch Dermatol. 2008 Jan;144(1):49-56. doi: 10.1001/archdermatol.2007.16.
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Primary dermal melanoma: a unique subtype of melanoma to be distinguished from cutaneous metastatic melanoma: a clinical, histologic, and gene expression-profiling study.原发性皮肤黑色素瘤：一种独特的黑色素瘤亚型，需要与皮肤转移性黑色素瘤相区分：一项临床、组织学和基因表达谱研究。
J Am Acad Dermatol. 2014 Dec;71(6):1083-92. doi: 10.1016/j.jaad.2014.07.051. Epub 2014 Sep 26.
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Primary dermal melanoma.原发性皮肤黑色素瘤。
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Primary Dermal Melanoma (PDM): Histological and Clinical Interdependence to Guide Therapy.原发性皮肤黑色素瘤（PDM）：指导治疗的组织学与临床相关性
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Primary Dermal Melanoma: A Rare Clinicopathological Variant Mimicking Metastatic Melanoma.原发性皮肤黑色素瘤：一种罕见的临床病理变异型，酷似转移性黑色素瘤。
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Case report of a primary subcutaneous melanoma; a surprising entity for a subcutaneous nodule.原发性皮下黑色素瘤病例报告；皮下结节的一个令人惊讶的病例。
Int J Surg Case Rep. 2021 Sep;86:106359. doi: 10.1016/j.ijscr.2021.106359. Epub 2021 Aug 31.

本文引用的文献

1
Primary Dermal Melanoma (PDM): Histological and Clinical Interdependence to Guide Therapy.原发性皮肤黑色素瘤（PDM）：指导治疗的组织学与临床相关性
J Cutan Med Surg. 2021 Jan-Feb;25(1):53-58. doi: 10.1177/1203475420957634. Epub 2020 Sep 10.
2
Utility of sentinel lymph node biopsy for solitary dermal melanomas.前哨淋巴结活检在孤立性皮肤黑色素瘤中的应用
J Surg Oncol. 2015 Jun;111(7):800-7. doi: 10.1002/jso.23890. Epub 2015 Feb 24.
3
Primary dermal melanoma: a unique subtype of melanoma to be distinguished from cutaneous metastatic melanoma: a clinical, histologic, and gene expression-profiling study.
原发性皮肤黑色素瘤：一种独特的黑色素瘤亚型，需要与皮肤转移性黑色素瘤相区分：一项临床、组织学和基因表达谱研究。
J Am Acad Dermatol. 2014 Dec;71(6):1083-92. doi: 10.1016/j.jaad.2014.07.051. Epub 2014 Sep 26.
4
Melanoma patients with an unknown primary tumor site have a better outcome than those with a known primary following therapeutic lymph node dissection for macroscopic (clinically palpable) nodal disease.对于原发性肿瘤部位不明的黑色素瘤患者，在针对肉眼可见（临床可触及）的淋巴结疾病进行治疗性淋巴结清扫后，其预后比原发性肿瘤部位已知的患者更好。
Ann Surg Oncol. 2014 Sep;21(9):3108-16. doi: 10.1245/s10434-014-3679-5. Epub 2014 May 7.
5
Primary dermal melanoma: distinct immunohistochemical findings and clinical outcome compared with nodular and metastatic melanoma.原发性皮肤黑色素瘤：与结节性和转移性黑色素瘤相比，具有独特的免疫组化表现和临床结局。
Arch Dermatol. 2008 Jan;144(1):49-56. doi: 10.1001/archdermatol.2007.16.
6
Primary dermal melanoma: a distinct subtype of melanoma.原发性皮肤黑色素瘤：黑色素瘤的一种独特亚型。
Arch Dermatol. 2004 Jan;140(1):99-103. doi: 10.1001/archderm.140.1.99.
7
Solitary melanoma confined to the dermal and/or subcutaneous tissue: evidence for revisiting the staging classification.局限于真皮和/或皮下组织的孤立性黑色素瘤：重新审视分期分类的证据
Arch Dermatol. 2000 Nov;136(11):1397-9. doi: 10.1001/archderm.136.11.1397.