Arrey Agbor Divine Besong, Zafar Wahib, Agyemang Emmanuel A, Nzeako Tochukwu, Ugwendum Derek, Forsah Sabastain F, Kankeu Tonpouwo Gauvain, Pokuaa Irene O, Grigos Angela, Nfonoyim Jay
Internal Medicine, Richmond University Medical Center, Staten Island, USA.
Hematology/Oncology, Richmond University Medical Center, Staten Island, USA.
Cureus. 2024 Jul 27;16(7):e65541. doi: 10.7759/cureus.65541. eCollection 2024 Jul.
Primary classic Hodgkin lymphoma (HL) of the breast is a rare type of breast disease. The diagnosis is mostly confirmed by an excisional biopsy. The first line of treatment commonly used for Hodgkin lymphoma is doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD). Our case report is about a 48-year-old lady who was diagnosed with bilateral breast Hodgkin lymphoma following an excisional biopsy and was treated with brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD). The patient responded positively after the initiation of the regimen. There is scarce data on the classic Hodgkin lymphoma of the breast, and even with the wide use of first-line treatment using ABVD, the disease is still difficult to manage. Hence, patients with breast masses should be screened for classic HL of the breast, and larger studies are needed to establish specific treatment guidelines concerning HL of the breast to prevent relapse and other complications.
原发性乳腺经典型霍奇金淋巴瘤（HL）是一种罕见的乳腺疾病。诊断大多通过切除活检来确诊。霍奇金淋巴瘤常用的一线治疗方案是多柔比星、博来霉素、长春碱和达卡巴嗪（ABVD）。我们的病例报告是关于一位48岁女性，她在切除活检后被诊断为双侧乳腺霍奇金淋巴瘤，并接受了维布妥昔单抗联合多柔比星、长春碱和达卡巴嗪（BV-AVD）治疗。该方案开始治疗后患者反应良好。关于乳腺经典型霍奇金淋巴瘤的数据稀少，即使广泛使用ABVD一线治疗，该疾病仍难以处理。因此，乳腺肿块患者应筛查乳腺经典型HL，并且需要开展更大规模的研究以制定关于乳腺HL的具体治疗指南，以预防复发和其他并发症。
