Wang Qiao, Wang Chong, Yang Xinyuan, Wang Jiali, Zhang Zhuohao, Shang Luoran
Shanghai Xuhui Central Hospital Zhongshan-Xuhui Hospital, and the Shanghai Key Laboratory of Medical Epigenetics the International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology) Institutes of Biomedical Sciences Fudan University Shanghai China.
Smart Med. 2023 Feb 12;2(1):e20220027. doi: 10.1002/SMMD.20220027. eCollection 2023 Feb.
Optical biosensors are platforms that translate biological information into detectable optical signals, and have extensive applications in various fields due to their characteristics of high sensitivity, high specificity, dynamic sensing, etc. The development of optical sensing materials is an important part of optical sensors. In this review, we emphasize the role of microfluidic technology in the preparation of optical sensing materials and the application of the derived optical sensors in the biomedical field. We first present some common optical sensing mechanisms and the functional responsive materials involved. Then, we describe the preparation of these sensing materials by microfluidics. Afterward, we enumerate the biomedical applications of these optical materials as biosensors in disease diagnosis, drug evaluation, and organ-on-a-chip. Finally, we discuss the challenges and prospects in this field.
光学生物传感器是将生物信息转化为可检测光信号的平台，因其具有高灵敏度、高特异性、动态传感等特性而在各个领域有着广泛的应用。光传感材料的开发是光传感器的重要组成部分。在本综述中，我们强调了微流控技术在光传感材料制备中的作用以及衍生出的光传感器在生物医学领域的应用。我们首先介绍一些常见的光传感机制以及所涉及的功能响应材料。然后，我们描述通过微流控技术制备这些传感材料的过程。之后，我们列举这些光学材料作为生物传感器在疾病诊断、药物评估和芯片器官等生物医学应用中的情况。最后，我们讨论该领域的挑战和前景。
