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基于人工蛛丝蛋白纳米发电机的关节伤口敷料。

Artificial Spidroin Nanogenerator-Based Articulus Wound Dressing.

作者信息

Ma Xiaoming, Li Shuhuan, Gao Bingbing

机构信息

Department of Orthopedics, Taizhou People's Hospital, Taizhou, Jiangsu Province, People's Republic of China.

School of Pharmaceutical Sciences, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.

出版信息

ChemistryOpen. 2025 Feb;14(2):e202400257. doi: 10.1002/open.202400257. Epub 2024 Oct 30.

DOI:10.1002/open.202400257
PMID:39473315
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11808259/
Abstract

Articulus wound infection is a threat to human health. Existing medical materials have poor biocompatibility and may contain harmful chemicals, causing allergies and secondary infections. Therefore, there is an urgent need to develop innovative medical materials. Materials made of artificial spider silk proteins have been widely used in wound healing because of their good biocompatibility, biodegradability, cell adhesion and bioelectronic properties.

摘要

关节伤口感染对人类健康构成威胁。现有的医用材料生物相容性差,可能含有有害化学物质,会引发过敏和二次感染。因此,迫切需要开发创新型医用材料。由人工蜘蛛丝蛋白制成的材料因其良好的生物相容性、生物降解性、细胞黏附性和生物电子特性,已被广泛应用于伤口愈合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/829e/11808259/5fd5a685631d/OPEN-14-e202400257-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/829e/11808259/2501a7af4779/OPEN-14-e202400257-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/829e/11808259/5fd5a685631d/OPEN-14-e202400257-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/829e/11808259/2501a7af4779/OPEN-14-e202400257-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/829e/11808259/5fd5a685631d/OPEN-14-e202400257-g002.jpg

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本文引用的文献

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Strategies for Making High-Performance Artificial Spider Silk Fibers.制造高性能人造蜘蛛丝纤维的策略。
Adv Funct Mater. 2024 Aug 28;34(35):2305040. doi: 10.1002/adfm.202305040. Epub 2023 Oct 10.
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Microfluidic preparation of optical sensors for biomedical applications.用于生物医学应用的光学传感器的微流体制备。
Smart Med. 2023 Feb 12;2(1):e20220027. doi: 10.1002/SMMD.20220027. eCollection 2023 Feb.
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Near-infrared light-responsive Nitric oxide microcarrier for multimodal tumor therapy.用于多模态肿瘤治疗的近红外光响应型一氧化氮微载体
Smart Med. 2023 Jun 14;2(3):e20230016. doi: 10.1002/SMMD.20230016. eCollection 2023 Aug.
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Armored probiotics for oral delivery.用于口服给药的包膜益生菌。
Smart Med. 2023 Jul 20;2(4):e20230019. doi: 10.1002/SMMD.20230019. eCollection 2023 Nov.
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Adverse effects and potential mechanisms of polystyrene microplastics (PS-MPs) on the blood-testis barrier.聚苯乙烯微塑料(PS-MPs)对血睾屏障的不良影响及其潜在机制。
Environ Geochem Health. 2024 Jun 7;46(7):238. doi: 10.1007/s10653-024-02033-z.
6
Tyrosine Mutation in the Characteristic Motif of the Amorphous Region of Spidroin for Self-Assembly Capability Enhancement.用于增强自组装能力的蛛丝蛋白无定形区域特征基序中的酪氨酸突变
ACS Omega. 2024 May 10;9(20):22441-22449. doi: 10.1021/acsomega.4c02477. eCollection 2024 May 21.
7
Effect of conventional and biodegradable microplastics on earthworms during vermicomposting process.传统和可生物降解微塑料在蚯蚓堆肥过程中对蚯蚓的影响。
Environ Geochem Health. 2024 May 2;46(6):189. doi: 10.1007/s10653-024-01974-9.
8
Kirigami-inspired artificial spidroin microneedles for wound patches.受剪纸启发的人工蛛丝蛋白 microneedles 用于伤口贴片。
Int J Biol Macromol. 2024 May;268(Pt 1):131838. doi: 10.1016/j.ijbiomac.2024.131838. Epub 2024 Apr 23.
9
triboelectric spider fibroin microneedle patches for comprehensive joint management.用于综合关节管理的摩擦电蜘蛛丝蛋白微针贴片
Mater Today Bio. 2024 Apr 4;26:101044. doi: 10.1016/j.mtbio.2024.101044. eCollection 2024 Jun.
10
Efficient Biosynthetic Fabrication of Spidroins with High Spinning Performance.高效生物合成具有高纺丝性能的蜘蛛丝蛋白。
Adv Sci (Weinh). 2024 Jun;11(22):e2400128. doi: 10.1002/advs.202400128. Epub 2024 Mar 23.