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改进血胸管理：低剂量胸膜内纤维蛋白溶解疗法作为替代方案的前景。

Revamping hemothorax management: The promise of low-dose intrapleural fibrinolytic therapy as an alternative.

作者信息

Mohamad Jailaini Mas Fazlin, Hashim Yusra, Abdul Hamid Mohamed Faisal

机构信息

Respiratory Unit, Faculty of Medicine Universiti Kebangsaan Malaysia (UKM) Kuala Lumpur Malaysia.

出版信息

Respirol Case Rep. 2024 Aug 26;12(8):e70012. doi: 10.1002/rcr2.70012. eCollection 2024 Aug.

DOI:10.1002/rcr2.70012
PMID:39188573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11347044/
Abstract

Surgical evacuation has long been the standard treatment for hemothorax. However, some patients are not suitable candidates for surgery. Intrapleural fibrinolytic therapy (IPFT) has recently emerged as an effective alternative for managing retained hemothorax. This case report describes two patients with retained hemothorax who were unfit for surgery and were successfully treated with IPFT at our centre. Both patients were deemed unsuitable for surgery due to comorbidities and their overall functional status. They received three cycles of IPFT, each consisting of 2.5 mg of alteplase. This treatment effectively evacuated the retained hemothorax, achieving complete radiological resolution without immediate or delayed complications up to 3 months post-discharge.

摘要

外科引流长期以来一直是血胸的标准治疗方法。然而，一些患者并不适合手术。胸膜内纤维蛋白溶解疗法（IPFT）最近已成为治疗残留血胸的一种有效替代方法。本病例报告描述了两名残留血胸患者，他们不适合手术，在我们中心接受IPFT治疗后获得成功。由于合并症及其整体功能状态，两名患者均被认为不适合手术。他们接受了三个周期的IPFT治疗，每个周期包括2.5毫克阿替普酶。这种治疗有效地排出了残留的血胸，在出院后长达3个月的时间里，影像学上完全消退，且无即刻或延迟并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e98/11347044/038c97abe534/RCR2-12-e70012-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e98/11347044/7280a416b982/RCR2-12-e70012-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e98/11347044/038c97abe534/RCR2-12-e70012-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e98/11347044/7280a416b982/RCR2-12-e70012-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e98/11347044/038c97abe534/RCR2-12-e70012-g003.jpg

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Revamping hemothorax management: The promise of low-dose intrapleural fibrinolytic therapy as an alternative.改进血胸管理：低剂量胸膜内纤维蛋白溶解疗法作为替代方案的前景。
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本文引用的文献

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Bleeding Risk With Combination Intrapleural Fibrinolytic and Enzyme Therapy in Pleural Infection: An International, Multicenter, Retrospective Cohort Study.胸腔感染中联合应用胸腔内纤维蛋白溶解酶和酶治疗的出血风险：一项国际性、多中心、回顾性队列研究。
Chest. 2022 Dec;162(6):1384-1392. doi: 10.1016/j.chest.2022.06.008. Epub 2022 Jun 16.
2
Lytic Therapy for Retained Traumatic Hemothorax: A Systematic Review and Meta-analysis.创伤性血胸遗留的溶解治疗：系统评价和荟萃分析。
Chest. 2019 Apr;155(4):805-815. doi: 10.1016/j.chest.2019.01.007. Epub 2019 Jan 18.
3
Intrapleural tissue plasminogen activator and deoxyribonuclease therapy for pleural infection.
胸膜内组织型纤溶酶原激活剂和脱氧核糖核酸酶治疗胸膜感染
J Thorac Dis. 2015 Jun;7(6):999-1008. doi: 10.3978/j.issn.2072-1439.2015.01.30.
4
VATS versus intrapleural streptokinase: A prospective, randomized, controlled clinical trial for optimum treatment of post-traumatic Residual Hemothorax.电视辅助胸腔镜手术与胸膜腔内链激酶治疗：一项关于创伤后残留血胸最佳治疗方法的前瞻性、随机、对照临床试验。
Injury. 2015 Sep;46(9):1749-52. doi: 10.1016/j.injury.2015.02.028. Epub 2015 Mar 12.
5
Tissue plasminogen activator potently stimulates pleural effusion via a monocyte chemotactic protein-1-dependent mechanism.组织型纤溶酶原激活剂通过单核细胞趋化蛋白-1依赖性机制强烈刺激胸腔积液。
Am J Respir Cell Mol Biol. 2015 Jul;53(1):105-12. doi: 10.1165/rcmb.2014-0017OC.
6
Hemothorax: Etiology, diagnosis, and management.血胸：病因、诊断和治疗。
Thorac Surg Clin. 2013 Feb;23(1):89-96, vi-vii. doi: 10.1016/j.thorsurg.2012.10.003. Epub 2012 Nov 3.
7
Early VATS for blunt chest trauma: a management technique underutilized by acute care surgeons.早期电视辅助胸腔镜手术治疗钝性胸部创伤：一种未被急诊外科医生充分利用的治疗技术。
J Trauma. 2011 Jul;71(1):102-5; discussion 105-7. doi: 10.1097/TA.0b013e3182223080.
8
American Society of Anaesthesiologists physical status classification.美国麻醉医师协会身体状况分级
Indian J Anaesth. 2011 Mar;55(2):111-5. doi: 10.4103/0019-5049.79879.
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Treatment of haemothorax.血胸的治疗。
Respir Med. 2010 Nov;104(11):1583-7. doi: 10.1016/j.rmed.2010.08.006.