Santos-Lobato Bruno Lopes, Schuh Artur Francisco S
Laboratório de Neuropatologia Experimental, Universidade Federal do Pará, Belém, Brazil.
Hospital Ophir Loyola, Belém, Brazil.
Front Neurol. 2024 Aug 12;15:1411468. doi: 10.3389/fneur.2024.1411468. eCollection 2024.
In the last decades, the association of household pesticide usage with Parkinson's disease (PD) has been poorly explored, with discordant results. Based on the Parkinson's Progression Markers Initiative (PPMI) cohort study, we analyzed (1) the association of household pesticide exposure with the development of PD and (2) the effect of household pesticides on progression of PD.
Data from participants of the "FOllow Up persons with Neurologic Disease" (FOUND study) included in the PPMI cohort database were analyzed. The PPMI FOUND study applied the Parkinson's Disease Risk Factor Questionnaire to collect information regarding the use of pesticides in non-work settings during periods of life, and the lifetime pesticide exposure for each participant was estimated. We defined a high use of pesticides if the exposure estimate had a z-score higher than one standard deviation from the mean. Also, we evaluated longitudinal data of people with PD to analyze the effect of high use of household pesticides on disease progression according to motor impairment, cognitive dysfunction, depressive symptoms, and modification of motor clinical phenotype.
We analyzed data from 206 people with PD and 64 healthy controls, almost all from the USA. High use of household pesticides was not associated with the odds of developing PD. Regarding PD progression, only cognitive dysfunction was associated with the high use of household fungicides (HR 5.64 per standard deviation increase in exposure estimate, 95% CI 1.41-22.6).
Chronic exposure to household pesticides may impact the clinical progression of PD, especially cognitive symptoms.
在过去几十年中，家庭农药使用与帕金森病（PD）之间的关联研究较少，结果也不一致。基于帕金森病进展标志物倡议（PPMI）队列研究，我们分析了（1）家庭农药暴露与PD发病的关联，以及（2）家庭农药对PD进展的影响。
分析了PPMI队列数据库中纳入的“神经疾病随访者”（FOUND研究）参与者的数据。PPMI FOUND研究应用帕金森病风险因素问卷收集生活期间非工作环境中农药使用的信息，并估算了每位参与者的终生农药暴露量。如果暴露估计值的z分数高于均值一个标准差，我们则定义为高农药使用量。此外，我们评估了PD患者的纵向数据，以分析家庭高农药使用量对根据运动障碍、认知功能障碍、抑郁症状和运动临床表型改变的疾病进展的影响。
我们分析了来自206名PD患者和64名健康对照者的数据，几乎所有人都来自美国。家庭高农药使用量与PD发病几率无关。关于PD进展，只有认知功能障碍与家庭高剂量使用杀真菌剂有关（暴露估计值每增加一个标准差，风险比为5.64，95%置信区间为1.41 - 22.6）。
长期接触家用农药可能会影响PD的临床进展，尤其是认知症状。
